4a22 A 1.9 BS01 TD4 A 1 N27 S53 D95 H96 H212 G213 H252 G253 S255 N274 V275 D276 T277 N26 S52 D94 H95 H198 G199 H238 G239 S241 N260 V261 D262 T263 D95 H96 H212 H252 N274 D94 H95 H198 H238 N260 4.1.2.13 0004332,0005576,0005829,0005886,0005975,0006096,0008270,0009274,0016829,0016832,0035375,0046872 Kd=6.8nM -logKd/Ki=8.49, IC50=3.2nM IC50=3.2nM P9WQA3 21949126 1344 PIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLT 4a22 A 1.9 BS02 ZN A 1 H96 H212 H252 H95 H198 H238 D95 H96 H212 H252 N274 D94 H95 H198 H238 N260 4.1.2.13 0004332,0005576,0005829,0005886,0005975,0006096,0008270,0009274,0016829,0016832,0035375,0046872 P9WQA3 21949126 1348 PIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLT 4a22 B 1.9 BS01 TD4 B 1 N27 S53 G55 D95 H96 H212 G213 G253 S255 N274 V275 D276 T277 N26 S52 G54 D94 H95 H198 G199 G239 S241 N260 V261 D262 T263 D95 H96 H212 H252 N274 D94 H95 H198 H238 N260 4.1.2.13 0004332,0005576,0005829,0005886,0005975,0006096,0008270,0009274,0016829,0016832,0035375,0046872 Kd=6.8nM -logKd/Ki=8.49, IC50=3.2nM IC50=3.2nM P9WQA3 21949126 1344 PIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLT 4a22 B 1.9 BS02 ZN B 1 H96 H212 H252 H95 H198 H238 D95 H96 H212 H252 N274 D94 H95 H198 H238 N260 4.1.2.13 0004332,0005576,0005829,0005886,0005975,0006096,0008270,0009274,0016829,0016832,0035375,0046872 P9WQA3 21949126 1345 PIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLT