4a03 A 1.65 BS01 MN A 1 D151 E153 E222 D141 E143 E212 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 22281742 401 GRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSG 4a03 A 1.65 BS02 F98 A 1 D151 S152 A176 S177 H200 W203 M205 S213 N218 K219 D141 S142 A166 S167 H190 W193 M195 S203 N208 K209 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 ic50=160nM IC50=2390nM, Ki=130nM P9WNS1 22281742 501 GRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSG 4a03 A 1.65 BS03 NDP A 1 G19 T21 G22 S23 I24 A46 G47 A49 H50 A69 A103 L104 A126 N127 K128 E129 M205 G206 N209 G9 T11 G12 S13 I14 A36 G37 A39 H40 A59 A93 L94 A116 N117 K118 E119 M195 G196 N199 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 22281742 601 GRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSG 4a03 B 1.65 BS01 MN B 1 D151 S152 E153 E222 D141 S142 E143 E212 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 22281742 401 GRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSG 4a03 B 1.65 BS02 F98 B 1 D151 S152 A176 S177 H200 W203 S213 N218 K219 D141 S142 A166 S167 H190 W193 S203 N208 K209 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 ic50=160nM IC50=2390nM, Ki=130nM P9WNS1 22281742 501 GRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSG 4a03 B 1.65 BS03 NDP B 1 G19 T21 G22 S23 I24 A46 G47 A49 H50 A69 A103 L104 A126 N127 K128 E129 M205 G206 N209 M267 G9 T11 G12 S13 I14 A36 G37 A39 H40 A59 A93 L94 A116 N117 K118 E119 M195 G196 N199 M257 1.1.1.267 0000287,0008299,0016491,0019288,0030145,0030604,0046872,0050897,0051483,0051484,0070402 P9WNS1 22281742 601 GRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQTGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPTWSMGPMNTLNSASLVNKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARERAQRAVSG