456c A 2.4 BS01 ZN A 1 H222 H226 H232 H113 H117 H123 H222 E223 H226 H232 H113 E114 H117 H123 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 10074939 272 TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 456c A 2.4 BS02 ZN A 2 H172 D174 H187 H200 H63 D65 H78 H91 H222 E223 H226 H232 H113 E114 H117 H123 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 10074939 273 TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 456c A 2.4 BS03 CA A 1 D179 G180 P181 S182 L184 D202 E205 D70 G71 P72 S73 L75 D93 E96 H222 E223 H226 H232 H113 E114 H117 H123 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 10074939 274 TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 456c A 2.4 BS04 CBP A 1 L184 L185 A186 L218 H222 E223 H226 H232 L239 F241 P242 I243 Y244 T245 L75 L76 A77 L109 H113 E114 H117 H123 L130 F132 P133 I134 Y135 T136 H222 E223 H226 H232 H113 E114 H117 H123 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=0.17nM -logKd/Ki=9.77, Ki=0.17nM P45452 10074939 1 TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 456c B 2.4 BS01 ZN B 1 H222 H226 H232 H112 H116 H122 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 10074939 272 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 456c B 2.4 BS02 ZN B 2 H172 D174 H187 H200 H62 D64 H77 H90 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 10074939 273 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 456c B 2.4 BS03 CA B 1 D179 G180 P181 S182 L184 D202 E205 D69 G70 P71 S72 L74 D92 E95 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 10074939 274 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 456c B 2.4 BS04 CBP B 1 A186 L218 H222 E223 H226 H232 L239 F241 P242 I243 Y244 T245 A76 L108 H112 E113 H116 H122 L129 F131 P132 I133 Y134 T135 H222 E223 H226 H232 H112 E113 H116 H122 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=0.17nM P45452 10074939 1 LKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG