3zrl A 2.48 BS01 peptide X 0 Y216 I228 F229 S261 V263 L266 V267 K271 Y288 E290 K292 F293 I296 Y179 I191 F192 S224 V226 L229 V230 K234 Y251 E253 K255 F256 I259 D181 K183 N186 D200 S219 D144 K146 N149 D163 S182 2.7.11.1,2.7.11.26 0004672,0005524,0006468 P49841 21764580 199 ~ 221 KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 3zrl A 2.48 BS02 ZRL A 1 F67 V70 K85 Y134 V135 L188 D200 F32 V35 K50 Y97 V98 L151 D163 D181 K183 N186 D200 S219 D144 K146 N149 D163 S182 2.7.11.1,2.7.11.26 0004672,0005524,0006468 ic50=0.16uM -logKd/Ki=6.80, IC50=0.16uM IC50=158.49nM P49841 21764580 1390 KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 3zrl B 2.48 BS01 peptide Y 0 I228 F229 V263 L266 V267 I270 K271 T275 Y288 E290 F293 P294 I296 I193 F194 V228 L231 V232 I235 K236 T240 Y253 E255 F258 P259 I261 D181 K183 N186 D200 S219 D146 K148 N151 D165 S184 2.7.11.1,2.7.11.26 0004672,0005524,0006468 P49841 21764580 201 ~ 222 KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 3zrl B 2.48 BS02 ZRL B 1 F67 V70 A83 K85 Y134 V135 L188 D200 F32 V35 A48 K50 Y99 V100 L153 D165 D181 K183 N186 D200 S219 D146 K148 N151 D165 S184 2.7.11.1,2.7.11.26 0004672,0005524,0006468 ic50=0.16uM IC50=158.49nM P49841 21764580 1390 KVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR