3zep A 2.35 BS01 1NX A 1 L828 K830 V836 A853 Y904 L905 G908 L956 D967 L15 K17 V23 A40 Y86 L87 G90 L138 D149 D949 A951 R953 N954 D967 D131 A133 R135 N136 D149 2.7.10.2 0004672,0004713,0005524,0006468 ic50=0.022uM -logKd/Ki=7.66, IC50=22nM IC50=22nM P52333 23541670 2099 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDML 3zep B 2.35 BS01 1NX B 1 L828 A853 E903 Y904 L905 C909 L956 L15 A37 E82 Y83 L84 C88 L135 D949 A951 R953 N954 D967 D128 A130 R132 N133 D146 2.7.10.2 0004672,0004713,0005524,0006468 ic50=0.022uM IC50=22nM P52333 23541670 2101 PTIFEERHLKYISQLGKGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVRSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWS 3zep C 2.35 BS01 1NX C 1 L828 A853 M902 Y904 L905 C909 L956 D967 L15 A37 M82 Y84 L85 C89 L136 D147 D949 A951 R953 N954 D967 D129 A131 R133 N134 D147 2.7.10.2 0004672,0004713,0005524,0006468 ic50=0.022uM IC50=22nM P52333 23541670 2101 PTIFEERHLKYISQLGKGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWS 3zep D 2.35 BS01 1NX D 1 L828 K830 V836 A853 Y904 L905 L956 D967 L15 K17 V23 A40 Y87 L88 L139 D150 D949 A951 R953 N954 D967 D132 A134 R136 N137 D150 2.7.10.2 0004672,0004713,0005524,0006468 ic50=0.022uM IC50=22nM P52333 23541670 2100 PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVRESPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLW