3wv2 A 2.3 BS01 ZN A 1 H222 H226 H232 H119 H123 H129 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 25192810 301 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGPGDED 3wv2 A 2.3 BS02 ZN A 2 H172 D174 H187 H200 H69 D71 H84 H97 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 25192810 302 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGPGDED 3wv2 A 2.3 BS03 CA A 1 D179 G180 S182 L184 D202 E205 D76 G77 S79 L81 D99 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 25192810 303 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGPGDED 3wv2 A 2.3 BS04 CA A 2 D162 N194 G196 D198 D59 N91 G93 D95 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 25192810 304 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGPGDED 3wv2 A 2.3 BS05 WGG A 1 L218 V219 H222 L239 F241 I243 Y244 T245 T247 F252 P255 L115 V116 H119 L136 F138 I140 Y141 T142 T144 F146 P149 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=12nM -logKd/Ki=7.92, IC50=12nM IC50=5.6nM P45452 25192810 306 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTHFMLPDDDVQGIQSLYGPGDED 3wv2 B 2.3 BS01 ZN B 1 H222 H226 H232 H117 H121 H127 H222 E223 H226 H232 H117 E118 H121 H127 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 25192810 301 YNVFTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGHFMLPDDDVQGIQSLYGP 3wv2 B 2.3 BS02 ZN B 2 H172 D174 H187 H200 H67 D69 H82 H95 H222 E223 H226 H232 H117 E118 H121 H127 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 25192810 302 YNVFTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGHFMLPDDDVQGIQSLYGP 3wv2 B 2.3 BS03 CA B 1 D179 G180 S182 L184 D202 E205 D74 G75 S77 L79 D97 E100 H222 E223 H226 H232 H117 E118 H121 H127 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 25192810 303 YNVFTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGHFMLPDDDVQGIQSLYGP 3wv2 B 2.3 BS04 CA B 2 D162 N194 G196 D198 D57 N89 G91 D93 H222 E223 H226 H232 H117 E118 H121 H127 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 25192810 304 YNVFTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGHFMLPDDDVQGIQSLYGP 3wv2 B 2.3 BS05 WGG B 1 L218 V219 H222 L239 F241 I243 Y244 T245 T247 F252 P255 L113 V114 H117 L134 F136 I138 Y139 T140 T142 F145 P148 H222 E223 H226 H232 H117 E118 H121 H127 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=12nM IC50=5.6nM P45452 25192810 306 YNVFTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGHFMLPDDDVQGIQSLYGP