3w54 A 2.3 BS01 FE A 1 E123 E162 H165 E266 E92 E131 H134 E235 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 Q26710 23487766 501 VWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLK 3w54 A 2.3 BS02 FE A 2 E162 E213 E266 E131 E182 E235 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 Q26710 23487766 502 VWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLK 3w54 A 2.3 BS03 RNB A 1 V92 C95 R96 R118 L122 M190 L212 A216 T219 V61 C64 R65 R87 L91 M159 L181 A185 T188 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 ic50=0.2nM -logKd/Ki=9.70, IC50=0.2nM IC50=4.0nM Q26710 23487766 504 VWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLK 3w54 B 2.3 BS01 FE B 1 E123 E162 H165 E266 E93 E132 H135 E236 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 Q26710 23487766 501 PVWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKK 3w54 B 2.3 BS02 FE B 2 E162 E213 E266 E132 E183 E236 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 Q26710 23487766 502 PVWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKK 3w54 B 2.3 BS03 RNB B 1 R96 R118 L122 L212 A216 T219 R66 R88 L92 L182 A186 T189 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 ic50=0.2nM IC50=4.0nM Q26710 23487766 504 PVWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKK 3w54 C 2.3 BS01 FE C 1 E123 E162 H165 E266 E92 E131 H134 E235 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 Q26710 23487766 501 VWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKKN 3w54 C 2.3 BS02 FE C 2 E162 E213 E266 E131 E182 E235 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 Q26710 23487766 502 VWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKKN 3w54 C 2.3 BS03 RNB C 1 R118 C119 L122 L212 A216 T219 Y220 R87 C88 L91 L181 A185 T188 Y189 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 ic50=0.2nM IC50=4.0nM Q26710 23487766 504 VWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKKN 3w54 D 2.3 BS01 FE D 1 E123 E162 H165 E266 E92 E131 H134 E235 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 Q26710 23487766 501 VWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVL 3w54 D 2.3 BS02 FE D 2 E162 E213 E266 E131 E182 E235 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 Q26710 23487766 502 VWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVL 3w54 D 2.3 BS03 RNB D 1 C95 R96 R118 C119 L122 L212 E215 A216 T219 C64 R65 R87 C88 L91 L181 E184 A185 T188 1.-.-.- 0005739,0005743,0008199,0009916,0010230,0016491,0046872 ic50=0.2nM IC50=4.0nM Q26710 23487766 504 VWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVL