3w4i A 2.5 BS01 FAD A 1 G7 A8 G9 I11 A36 D37 R38 T45 A48 G50 L51 V164 T182 W185 G281 R283 G312 G313 Y314 G315 L316 T317 G7 A8 G9 I11 A36 D37 R38 T45 A48 G50 L51 V164 T182 W185 G281 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 23566269 401 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3w4i A 2.5 BS02 8LG A 1 Y224 Y228 R283 G313 Y224 Y228 R283 G313 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 ic50=1150nM P14920 23566269 402 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3w4i B 2.5 BS01 FAD B 1 G7 A8 G9 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 R283 G312 G313 Y314 G315 L316 T317 G7 A8 G9 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 23566269 401 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3w4i B 2.5 BS02 8LG B 1 Y224 Y228 R283 G313 Y224 Y228 R283 G313 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 ic50=1150nM P14920 23566269 402 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3w4i C 2.5 BS01 FAD C 1 G7 A8 G9 V10 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 G7 A8 G9 V10 I11 A36 D37 R38 T44 T45 A48 G50 L51 K163 V164 T182 W185 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 23566269 401 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3w4i C 2.5 BS02 8LG C 1 Y224 Y228 R283 G313 Y224 Y228 R283 G313 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 ic50=1150nM P14920 23566269 402 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3w4i D 2.5 BS01 FAD D 1 G7 A8 G9 V10 I11 A36 D37 R38 T45 A48 L51 K163 V164 T182 G281 R283 G312 G313 Y314 G315 L316 T317 G7 A8 G9 V10 I11 A36 D37 R38 T45 A48 L51 K163 V164 T182 G281 R283 G312 G313 Y314 G315 L316 T317 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 P14920 23566269 401 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS 3w4i D 2.5 BS02 8LG D 1 Y224 Y228 R283 G313 Y224 Y228 R283 G313 L51 G313 T317 L51 G313 T317 1.4.3.3 0003884,0005515,0005576,0005737,0005741,0005777,0005782,0005829,0006562,0007586,0016491,0019478,0036088,0042416,0042802,0042995,0045202,0046416,0048786,0055130,0070178,0070945,0071949 ic50=1150nM P14920 23566269 402 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS