3vqs A 1.9 BS01 JT1 A 1 V179 Y191 F193 Y195 S196 P197 R200 S288 C289 C366 S368 L384 M414 Y415 I447 Y448 Y452 L466 L547 F551 V179 Y191 F193 Y195 S196 P197 R200 S288 C289 C366 S368 L384 M414 Y415 I447 Y448 Y452 L466 L547 F551 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0003723,0003968,0039694 ic50=0.0178uM -logKd/Ki=7.75, IC50=0.0178uM P26663 22615294 1000 SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVA 3vqs B 1.9 BS01 JT1 B 1 Y191 F193 Y195 S196 P197 R200 S288 C289 C366 S368 L384 M414 Y415 I447 Y448 Y452 L466 Y555 Y191 F193 Y195 S196 P197 R200 S288 C289 C366 S368 L384 M414 Y415 I447 Y448 Y452 L466 Y555 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0003723,0003968,0039694 ic50=0.0178uM P26663 22615294 601 SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYSG 3vqs C 1.9 BS01 JT1 C 1 V179 Y191 F193 Y195 S196 P197 R200 S288 C289 C366 S368 L384 M414 Y415 I447 Y448 Y452 L466 Y555 S556 V179 Y191 F193 Y195 S196 P197 R200 S288 C289 C366 S368 L384 M414 Y415 I447 Y448 Y452 L466 Y555 S556 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0003723,0003968,0039694 ic50=0.0178uM P26663 22615294 601 SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYS 3vqs D 1.9 BS01 JT1 D 1 V179 Y191 F193 Y195 S196 P197 R200 S288 C289 C366 S368 L384 M414 Y415 I447 Y448 Y452 L466 L547 F551 V179 Y191 F193 Y195 S196 P197 R200 S288 C289 C366 S368 L384 M414 Y415 I447 Y448 Y452 L466 L547 F551 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0003723,0003968,0039694 ic50=0.0178uM P26663 22615294 1000 SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSKFGYGAKDVRNLSSKAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAASQLDLSGWFVA