3v8s A 2.286 BS01 0HD A 1 R84 G85 G88 E89 V90 A103 K105 M153 E154 Y155 M156 L205 D216 R77 G78 G81 E82 V83 A96 K98 M146 E147 Y148 M149 L198 D209 D198 K200 N203 D216 T237 D191 K193 N196 D209 T230 2.7.11.1 0004672,0004674,0005524,0006468 ic50=0.65uM -logKd/Ki=6.19, IC50=0.65uM IC50=650nM Q13464 22272748 501 ETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN 3v8s B 2.286 BS01 0HD B 1 R84 G85 E89 V90 A103 K105 M153 Y155 M156 L205 D216 R79 G80 E84 V85 A98 K100 M148 Y150 M151 L200 D211 D198 K200 N203 D216 T237 D193 K195 N198 D211 T232 2.7.11.1 0004672,0004674,0005524,0006468 ic50=0.65uM IC50=650nM Q13464 22272748 501 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN 3v8s C 2.286 BS01 0HD C 1 G85 G88 E89 V90 A103 K105 M153 Y155 M156 L205 D216 G78 G81 E82 V83 A96 K98 M146 Y148 M149 L198 D209 D198 K200 N203 D216 T237 D191 K193 N196 D209 T230 2.7.11.1 0004672,0004674,0005524,0006468 ic50=0.65uM IC50=650nM Q13464 22272748 501 ETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN 3v8s D 2.286 BS01 0HD D 1 R84 G85 V90 A103 K105 M153 Y155 M156 L205 D216 R79 G80 V85 A98 K100 M148 Y150 M151 L200 D211 D198 K200 N203 D216 T237 D193 K195 N198 D211 T232 2.7.11.1 0004672,0004674,0005524,0006468 ic50=0.65uM IC50=650nM Q13464 22272748 501 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN