3v11 A 5.0 BS01 peptide C 0 P65 V151 K156 A159 Y163 R164 K167 I181 P182 V183 I189 N190 D192 S193 P59 V145 K150 A153 Y157 R158 K161 I175 P176 V177 I183 N184 D186 S187 D19 K22 T23 T46 H97 D13 K16 T17 T40 H91 3.6.5.3 0000049,0001731,0003743,0003746,0003924,0005515,0005525,0006412,0006413,0006414,0016787,0046872 Q980A5 22447243 3 ~ 19 QPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 3v11 A 5.0 BS02 rna D 0 S35 H37 S38 E39 F221 V223 P226 S278 R280 A296 S29 H31 S32 E33 F215 V217 P220 S267 R269 A285 D19 K22 T23 T46 H97 D13 K16 T17 T40 H91 3.6.5.3 0000049,0001731,0003743,0003746,0003924,0005515,0005525,0006412,0006413,0006414,0016787,0046872 Kd=1nM Q980A5 22447243 2 ~ 76 QPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 3v11 A 5.0 BS03 MG A 1 T23 K36 T46 T17 K30 T40 D19 K22 T23 T46 H97 D13 K16 T17 T40 H91 3.6.5.3 0000049,0001731,0003743,0003746,0003924,0005515,0005525,0006412,0006413,0006414,0016787,0046872 Q980A5 22447243 501 QPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 3v11 A 5.0 BS04 GNP A 1 V18 D19 G21 K22 T23 T24 K36 M45 G96 N149 K150 D152 L186 V12 D13 G15 K16 T17 T18 K30 M39 G90 N143 K144 D146 L180 D19 K22 T23 T46 H97 D13 K16 T17 T40 H91 3.6.5.3 0000049,0001731,0003743,0003746,0003924,0005515,0005525,0006412,0006413,0006414,0016787,0046872 Q980A5 22447243 502 QPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 3v11 A 5.0 BS05 MET D 1 Y51 R219 R280 F281 L294 V295 A296 Y45 R213 R269 F270 L283 V284 A285 D19 K22 T23 T46 H97 D13 K16 T17 T40 H91 3.6.5.3 0000049,0001731,0003743,0003746,0003924,0005515,0005525,0006412,0006413,0006414,0016787,0046872 Q980A5 22447243 101 QPEVNIGVVGHVDHGKTTLVQAITGIWTSKHSEELKRGMTIKLGYAETNIGVCESCKKPEAYVTEPSCKSCGSDDEPKFLRRISFIDAPGHEVLMATMLSGAALMDGAILVVAANEPFPQPQTREHFVALGIIGVKNLIIVQNKVDVVSKEEALSQYRQIKQFTKGTWAENVPIIPVSALHKINIDSLIEGIEEYIKTPYRDLSQKPVMLVIRSFDVNKPGTQFNELKGGVIGGSIIQGLFKVDQEIKVLPGLRVVSYEPIFTKISSIRFGDEEFKEAKPGGLVAIGTYLDPSLTKADNLLGSIITLADAEVPVLWNIRIKYNLLERVVGAKEMLKVDPIRAKETLMLSVGSSTTLGIVTSVKKDEIEVELRRPVAVWSNNIRTVISRQIAGRWRMIGWGLVEI 3v11 B 5.0 BS01 rna D 0 N53 R62 N94 W97 Q101 K105 N48 R57 N89 W92 Q96 K100 ? 0003676,0003723,0003743,0005515,0006412,0006413,0043022 Kd=1nM Q97Z79 22447243 2 ~ 76 MIYSRSKLPSEGEILIATVKQVFDYGSYVSLDEYGGLQAFLPWSEVSNIRDVLKENRKVIVKVIRVDRRKGTVDVSLKKVTDDERRKKNLQWKKIQRLDKILELVSQKLKLSEKDAWEQVAWKLEAKYGDPITAIEKAVKEGEKILIDAGVPEIWVKPLLEEASRKVKMSGLITVRTNEPLGVEKIKEVISKALENIEQDYESLLNIKIYTIGAPRYRVDVVGTNPKEASEALNQIISNLIKIGKEENVDISVV