3v01 A 2.705 BS01 3V0 A 1 G77 N78 K97 V127 D208 F209 G210 V211 S212 L215 I216 G17 N18 K37 V67 D148 F149 G150 V151 S152 L155 I156 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T163 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=7.60, IC50=25nM IC50=25nM, EC50=6.3nM Q02750 22506516 501 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3v01 A 2.705 BS02 ATP A 1 A76 G77 N78 V82 A95 K97 M143 M146 Q153 K192 S194 L197 A16 G17 N18 V22 A35 K37 M83 M86 Q93 K132 S134 L137 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T163 2.7.12.2 0004672,0005524,0006468 Q02750 22506516 502 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN 3v01 A 2.705 BS03 MG A 1 N195 D208 N135 D148 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T163 2.7.12.2 0004672,0005524,0006468 Q02750 22506516 503 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN