3uu1 A 1.82 BS01 PRP A 1 V106 G107 G109 G110 N117 S119 T120 K135 R139 A140 G146 V82 G83 G85 G86 N93 S95 T96 K111 R115 A116 G118 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 401 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 A 1.82 BS02 MG A 1 S119 E252 S95 E224 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 402 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 A 1.82 BS03 MG A 2 D251 E252 D223 E224 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 403 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 A 1.82 BS04 14B A 1 N138 A179 P180 H183 Y186 A190 N114 A151 P152 H155 Y158 A162 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 -logKd/Ki=5.20, Ki=6.3uM P9WFX5 23363292 404 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 B 1.82 BS01 PRP B 1 V106 G107 G109 G110 N117 S119 T120 K135 N138 R139 A140 G146 E252 V82 G83 G85 G86 N93 S95 T96 K111 N114 R115 A116 G118 E224 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 401 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 B 1.82 BS02 MG B 1 S119 E252 S95 E224 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 402 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 B 1.82 BS03 MG B 2 D251 E252 D223 E224 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 403 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 B 1.82 BS04 14B B 1 N138 P180 H183 Y186 R187 A190 R194 N114 P152 H155 Y158 R159 A162 R166 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 404 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 B 1.82 BS05 14B B 2 H136 G137 N138 A179 R193 G206 H112 G113 N114 A151 R165 G178 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 405 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 C 1.82 BS01 PRP C 1 V106 G107 G109 G110 N117 S119 T120 K135 N138 R139 A140 A141 G146 E252 V82 G83 G85 G86 N93 S95 T96 K111 N114 R115 A116 A117 G119 E225 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 401 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 C 1.82 BS02 MG C 1 S119 E252 S95 E225 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 402 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 C 1.82 BS03 MG C 2 D251 E252 D224 E225 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 403 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 C 1.82 BS04 14B C 1 N138 P180 Y186 R187 A190 R194 N114 P153 Y159 R160 A163 R167 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 404 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 C 1.82 BS05 14B C 2 H136 G137 N138 A179 R193 G206 H112 G113 N114 A152 R166 G179 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 405 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 D 1.82 BS01 PRP D 1 V106 G109 G110 N117 S119 T120 K135 R139 E252 V82 G85 G86 N93 S95 T96 K111 R115 E224 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 401 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 D 1.82 BS02 14B D 1 N138 A179 P180 H183 Y186 A190 R194 N114 A151 P152 H155 Y158 A162 R166 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 402 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 D 1.82 BS03 MG D 1 S119 E252 S95 E224 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 403 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI 3uu1 D 1.82 BS04 MG D 2 D251 E252 D223 E224 V106 V82 2.4.2.18 0000162,0000287,0004048,0005576,0005829,0005886,0016757,0016763,0046872 P9WFX5 23363292 404 PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRASGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI