3ug8 A 1.73 BS01 NAP A 1 G22 T23 Y24 D50 Y55 H117 N167 Q190 Y216 S217 L219 S221 Q222 L236 A253 L268 K270 S271 R276 Q279 N280 G17 T18 Y19 D45 Y50 H112 N149 Q172 Y198 S199 L201 S203 Q204 L218 A235 L250 K252 S253 R258 Q261 N262 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.188,1.1.1.210,1.1.1.239,1.1.1.357,1.1.1.53,1.1.1.62,1.1.1.64 0001523,0001758,0004032,0004033,0004303,0004745,0005515,0005634,0005737,0005829,0006629,0006693,0007186,0007584,0008202,0008284,0008584,0009267,0016488,0016491,0016655,0019371,0030216,0032052,0035410,0036130,0036131,0042448,0042572,0042574,0043170,0044597,0044598,0045550,0045703,0047017,0047020,0047023,0047024,0047035,0047044,0047045,0047086,0047787,0048385,0051897,0052650,0061370,0070062,0070293,0071277,0071379,0071384,0071395,0071799,1900053,2000224,2000353,2000379 P42330 22937138 1001 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSD 3ug8 A 1.73 BS02 IMN A 1 Y55 H117 M120 N167 Y216 S217 F306 P318 Y319 Y50 H112 M115 N149 Y198 S199 F288 P300 Y301 D50 Y55 K84 H117 D45 Y50 K79 H112 1.1.1.-,1.1.1.188,1.1.1.210,1.1.1.239,1.1.1.357,1.1.1.53,1.1.1.62,1.1.1.64 0001523,0001758,0004032,0004033,0004303,0004745,0005515,0005634,0005737,0005829,0006629,0006693,0007186,0007584,0008202,0008284,0008584,0009267,0016488,0016491,0016655,0019371,0030216,0032052,0035410,0036130,0036131,0042448,0042572,0042574,0043170,0044597,0044598,0045550,0045703,0047017,0047020,0047023,0047024,0047035,0047044,0047045,0047086,0047787,0048385,0051897,0052650,0061370,0070062,0070293,0071277,0071379,0071384,0071395,0071799,1900053,2000224,2000353,2000379 IC50=2300nM, Ki=270nM P42330 22937138 2001 QCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHYFNSDSFASHPNYPYSD