3tv7 A 2.75 BS01 07Q A 1 G85 F87 G88 V90 A103 K105 Y155 M156 L205 A215 D216 G77 F79 G80 V82 A95 K97 Y147 M148 L197 A207 D208 D198 K200 N203 D216 T237 D190 K192 N195 D208 T229 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=7.52, IC50=30nM IC50=30nM Q13464 23275831 1 TRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN 3tv7 B 2.75 BS01 07Q B 1 G85 F87 G88 V90 A103 K105 M153 M156 L205 D216 F368 G80 F82 G83 V85 A98 K100 M148 M151 L200 D211 F363 D198 K200 N203 D216 T237 D193 K195 N198 D211 T232 2.7.11.1 0004672,0004674,0005524,0006468 IC50=30nM Q13464 23275831 2 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN 3tv7 C 2.75 BS01 07Q C 1 G85 F87 G88 E89 A103 K105 L107 M153 M156 A215 D216 G77 F79 G80 E81 A95 K97 L99 M145 M148 A207 D208 D198 K200 N203 D216 T237 D190 K192 N195 D208 T229 2.7.11.1 0004672,0004674,0005524,0006468 IC50=30nM Q13464 23275831 3 TRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN 3tv7 D 2.75 BS01 07Q D 1 G85 F87 G88 E89 V90 A103 K105 L107 M153 M156 D216 G80 F82 G83 E84 V85 A98 K100 L102 M148 M151 D211 D198 K200 N203 D216 T237 D193 K195 N198 D211 T232 2.7.11.1 0004672,0004674,0005524,0006468 IC50=30nM Q13464 23275831 4 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN