3tcp A 2.69 BS01 CKJ A 1 V601 A617 F673 M674 K675 R727 M730 V20 A36 F86 M87 K88 R140 M143 D723 A725 R727 N728 D741 D136 A138 R140 N141 D154 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=8.37, Ki=4.3nM IC50=2.9nM, Ki=4.3nM Q12866 22662287 1 LEDVVIDRNLLILGKILGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPD 3tcp B 2.69 BS01 CKJ B 1 A617 M674 R727 M730 A39 M82 R135 M138 D723 A725 R727 N728 D741 M762 D131 A133 R135 N136 D149 M151 2.7.10.1 0004672,0004713,0005524,0006468 IC50=2.9nM, Ki=4.3nM Q12866 22662287 2 KLEDVVIDRNLLILGKILGEGSVMEGNLKQEDGTSLKVAVKTMKEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL 3tcp B 2.69 BS02 CA B 1 Q821 D827 Q210 D216 D723 A725 R727 N728 D741 M762 D131 A133 R135 N136 D149 M151 2.7.10.1 0004672,0004713,0005524,0006468 Q12866 22662287 11 KLEDVVIDRNLLILGKILGEGSVMEGNLKQEDGTSLKVAVKTMKEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL