3rv3 A 1.91 BS01 ADP A 1 Y82 G83 G164 G165 R167 F193 K238 R292 Q294 V295 E296 R338 D382 Y85 G86 G167 G168 R170 F196 K241 R295 Q297 V298 E299 R341 D385 K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338 K119 K162 D199 H212 R238 T277 E279 E291 N293 R295 E299 R341 6.3.4.14 0003824,0003989,0004075,0005515,0005524,0005737,0005829,0006633,0009317,0016874,0042803,0045717,0046872,2001295 -logKd/Ki=2.00, IC50=10mM P24182 21592965 1000 GSHMLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKL 3rv3 A 1.91 BS02 ADP A 2 K116 K159 G164 G165 G166 M169 E201 K202 Y203 L204 H209 Q233 H236 L278 E288 I437 K119 K162 G167 G168 G169 M172 E204 K205 Y206 L207 H212 Q236 H239 L281 E291 I440 K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338 K119 K162 D199 H212 R238 T277 E279 E291 N293 R295 E299 R341 6.3.4.14 0003824,0003989,0004075,0005515,0005524,0005737,0005829,0006633,0009317,0016874,0042803,0045717,0046872,2001295 -logKd/Ki=2.00, IC50=10mM P24182 21592965 1002 GSHMLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKL 3rv3 A 1.91 BS03 MG A 1 E276 E288 E279 E291 K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338 K119 K162 D199 H212 R238 T277 E279 E291 N293 R295 E299 R341 6.3.4.14 0003824,0003989,0004075,0005515,0005524,0005737,0005829,0006633,0009317,0016874,0042803,0045717,0046872,2001295 P24182 21592965 1004 GSHMLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKL 3rv3 B 1.91 BS01 ADP B 1 K116 K159 G164 G166 M169 E201 K202 Y203 L204 H209 Q233 H236 L278 I287 E288 I437 K116 K159 G164 G166 M169 E201 K202 Y203 L204 H209 Q233 H236 L278 I287 E288 I437 K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338 K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338 6.3.4.14 0003824,0003989,0004075,0005515,0005524,0005737,0005829,0006633,0009317,0016874,0042803,0045717,0046872,2001295 P24182 21592965 1001 MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLGLQ 3rv3 B 1.91 BS02 ADP B 2 Y82 G83 G164 G165 F193 K238 R292 Q294 V295 E296 R338 D382 Y82 G83 G164 G165 F193 K238 R292 Q294 V295 E296 R338 D382 K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338 K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338 6.3.4.14 0003824,0003989,0004075,0005515,0005524,0005737,0005829,0006633,0009317,0016874,0042803,0045717,0046872,2001295 P24182 21592965 1003 MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLGLQ 3rv3 B 1.91 BS03 MG B 1 E276 E288 E276 E288 K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338 K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338 6.3.4.14 0003824,0003989,0004075,0005515,0005524,0005737,0005829,0006633,0009317,0016874,0042803,0045717,0046872,2001295 P24182 21592965 1005 MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLGLQ