3ruk A 2.6 BS01 HEM A 1 R96 I112 A113 R125 A302 T306 L361 V366 L370 H373 P434 F435 R440 C442 I443 G444 A448 R66 I82 A83 R95 A263 T267 L322 V327 L331 H334 P395 F396 R401 C403 I404 G405 A409 T306 F435 C442 T267 F396 C403 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 P05093 22266943 600 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 3ruk A 2.6 BS02 AER A 1 A113 N202 D298 A302 A83 N172 D259 A263 T306 F435 C442 T267 F396 C403 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 IC50=72nM P05093 22266943 601 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 3ruk B 2.6 BS01 HEM B 1 R96 I112 A113 R125 A302 G303 T306 T307 V366 L370 I371 H373 P434 F435 R440 C442 I443 G444 A448 R66 I82 A83 R95 A264 G265 T268 T269 V328 L332 I333 H335 P396 F397 R402 C404 I405 G406 A410 T306 F435 C442 T268 F397 C404 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 P05093 22266943 600 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 3ruk B 2.6 BS02 AER B 1 A113 N202 I205 I206 T306 A83 N172 I175 I176 T268 T306 F435 C442 T268 F397 C404 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 IC50=72nM P05093 22266943 601 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 3ruk C 2.6 BS01 HEM C 1 R96 I112 A113 W121 R125 A302 T306 V366 L370 I371 H373 P434 F435 R440 C442 R66 I82 A83 W91 R95 A272 T276 V336 L340 I341 H343 P404 F405 R410 C412 T306 F435 C442 T276 F405 C412 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 P05093 22266943 600 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREA 3ruk C 2.6 BS02 AER C 1 A113 Y201 N202 T306 A83 Y171 N172 T276 T306 F435 C442 T276 F405 C412 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 IC50=72nM P05093 22266943 601 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREA 3ruk D 2.6 BS01 HEM D 1 R96 I112 A113 W121 R125 I299 A302 G303 T306 V366 L370 H373 P434 F435 R440 C442 G444 R66 I82 A83 W91 R95 I269 A272 G273 T276 V336 L340 H343 P404 F405 R410 C412 G414 T306 F435 C442 T276 F405 C412 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 P05093 22266943 600 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 3ruk D 2.6 BS02 AER D 1 A113 Y201 N202 D298 T306 V366 A83 Y171 N172 D268 T276 V336 T306 F435 C442 T276 F405 C412 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0046872 IC50=72nM P05093 22266943 601 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ