3qs1 A 3.1 BS01 006 A 1 D32 G34 Y75 V76 S77 D215 G217 T218 S219 D33 G35 Y76 V77 S78 D213 G215 T216 S217 D32 S35 N37 W39 Y75 D215 T218 D33 S36 N38 W40 Y76 D213 T216 3.4.23.38 0004190,0006508 -logKd/Ki=7.96, Ki=11.0nM IC50=280nM P39898 21521654 330 AGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFILGDPFMRKYFTVFDYDNHTVGFALAKKK 3qs1 B 3.1 BS01 006 B 1 D32 G34 N74 Y75 V76 S77 L128 D215 G217 T218 S219 I300 D33 G35 N75 Y76 V77 S78 L130 D213 G215 T216 S217 I299 D32 S35 N37 W39 Y75 D215 T218 D33 S36 N38 W40 Y76 D213 T216 3.4.23.38 0004190,0006508 -logKd/Ki=7.96, Ki=11.0nM IC50=280nM P39898 21521654 330 AGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFILGDPFMRKYFTVFDYDNHTVGFALAKKK 3qs1 C 3.1 BS01 006 C 1 D32 G34 S35 Y75 V76 S77 I130 D215 G217 T218 S219 I287 D32 G34 S35 Y75 V76 S77 I131 D212 G214 T215 S216 I288 D32 S35 N37 W39 Y75 D215 T218 D32 S35 N37 W39 Y75 D212 T215 3.4.23.38 0004190,0006508 IC50=280nM P39898 21521654 330 GDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFILGDPFMRKYFTVFDYDNHTVGFALAKKK 3qs1 D 3.1 BS01 006 D 1 D32 G34 Y75 V76 S77 I130 Y189 D215 T218 S219 I287 L291 I300 D32 G34 Y75 V76 S77 I131 Y190 D212 T215 S216 I288 L292 I298 D32 S35 N37 W39 Y75 D215 T218 D32 S35 N37 W39 Y75 D212 T215 3.4.23.38 0004190,0006508 IC50=280nM P39898 21521654 330 GDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNLYDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTLGQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRFYEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVVKIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKNTFILGDPFMRKYFTVFDYDNHTVGFALAKKK