3qce A 2.1 BS01 NXY A 1 I950 Y1023 W1026 G1030 V1031 P1032 V1038 F1041 R1066 Y1070 E1107 Q1108 F1111 I124 Y184 W187 G191 V192 P193 V199 F202 R227 Y231 E268 Q269 F272 E955 D1028 C1060 R1066 T1067 Q1104 E129 D189 C221 R227 T228 Q265 3.1.3.48 0004725,0006470,0016311 Ki=2.5uM Ki=2500nM, IC50=2500nM P23470 21882820 2001 MEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV 3qce B 2.1 BS01 NXY B 1 I950 Y1023 W1026 V1031 V1038 F1041 R1066 Y1070 Q1108 F1111 I125 Y185 W188 V193 V200 F203 R228 Y232 Q270 F273 E955 D1028 C1060 R1066 T1067 Q1104 E130 D190 C222 R228 T229 Q266 3.1.3.48 0004725,0006470,0016311 Ki=2.5uM -logKd/Ki=5.60, Ki=2.5uM Ki=2500nM, IC50=2500nM P23470 21882820 2001 MEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILG