3qc9 A 2.7 BS01 ADP A 1 L193 G194 R195 G196 V201 A214 K216 M267 L321 D332 L163 G164 R165 G166 V171 A184 K186 M237 L291 D302 D314 K316 E318 N319 D332 A341 T352 D284 K286 E288 N289 D302 A311 T322 2.7.11.14 0001750,0004672,0004674,0004703,0005515,0005524,0005737,0006468,0007165,0007601,0009966,0016020,0016310,0022400,0042995,0046777,0050254,0097381 -logKd/Ki=6.06, Kd=0.88uM P28327 21265573 700 RDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRP 3qc9 B 2.7 BS01 ADP B 1 L193 G194 G196 V201 A214 K216 M264 M267 L321 D332 L163 G164 G166 V171 A184 K186 M234 M237 L291 D302 D314 K316 E318 N319 D332 A341 T352 D284 K286 E288 N289 D302 A311 T322 2.7.11.14 0001750,0004672,0004674,0004703,0005515,0005524,0005737,0006468,0007165,0007601,0009966,0016020,0016310,0022400,0042995,0046777,0050254,0097381 P28327 21265573 700 RDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRP 3qc9 B 2.7 BS02 MG B 1 D332 G334 D302 G304 D314 K316 E318 N319 D332 A341 T352 D284 K286 E288 N289 D302 A311 T322 2.7.11.14 0001750,0004672,0004674,0004703,0005515,0005524,0005737,0006468,0007165,0007601,0009966,0016020,0016310,0022400,0042995,0046777,0050254,0097381 P28327 21265573 801 RDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRP 3qc9 C 2.7 BS01 ADP C 1 R195 A214 K216 M264 M267 L321 D332 R160 A179 K181 M229 M232 L286 D297 D314 K316 E318 N319 D332 A341 T352 D279 K281 E283 N284 D297 A306 T317 2.7.11.14 0001750,0004672,0004674,0004703,0005515,0005524,0005737,0006468,0007165,0007601,0009966,0016020,0016310,0022400,0042995,0046777,0050254,0097381 P28327 21265573 700 RDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARALFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDSVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRP 3qc9 D 2.7 BS01 ADP D 1 L193 G194 R195 V201 A214 K216 M267 L321 D332 L163 G164 R165 V171 A184 K186 M237 L291 D302 D314 K316 E318 N319 D332 A341 T352 D284 K286 E288 N289 D302 A311 T322 2.7.11.14 0001750,0004672,0004674,0004703,0005515,0005524,0005737,0006468,0007165,0007601,0009966,0016020,0016310,0022400,0042995,0046777,0050254,0097381 P28327 21265573 700 RDRKYLARLKLPPLSKCEALRESLDLGFEGMCLEQPIGKRLFQQFLRTHEQHGPALQLWKDIEDYDTADDALRPQKAQALRAAYLEPQAQLFCSFLDAETVARARAGAGDGLFQPLLRAVLAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEAGMLTPPFVPDVKGVAFEKADTEFFQEFASGTCPIPWQEEMIETGVFGDLNVWRP