3q2h A 2.33 BS01 ZN A 1 H149 H153 H159 H146 H150 H156 3.4.24.- 0004222,0006508,0008237 Q9UHI8 21300546 401 SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPTCSTLWCTGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKLVP 3q2h A 2.33 BS02 MG A 1 H187 N290 H180 N275 3.4.24.- 0004222,0006508,0008237 Q9UHI8 21300546 621 SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPTCSTLWCTGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKLVP 3q2h A 2.33 BS03 QHF A 1 T117 G119 F145 H149 E150 H153 H159 S180 L182 T114 G116 F142 H146 E147 H150 H156 S173 L175 3.4.24.- 0004222,0006508,0008237 ic50=0.69nM -logKd/Ki=9.16, IC50=690pM Q9UHI8 21300546 1 SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPTCSTLWCTGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKLVP 3q2h B 2.33 BS01 ZN B 1 H149 H153 H159 H146 H150 H156 3.4.24.- 0004222,0006508,0008237 Q9UHI8 21300546 402 SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNSHMMASMLNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCTCSTLWCTGTLVCQTKHFPWADGTSCGEGKWCINGKCVNKLVPR 3q2h B 2.33 BS02 MG B 1 H187 D278 N290 H178 D260 N272 3.4.24.- 0004222,0006508,0008237 Q9UHI8 21300546 616 SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNSHMMASMLNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCTCSTLWCTGTLVCQTKHFPWADGTSCGEGKWCINGKCVNKLVPR 3q2h B 2.33 BS03 QHF B 1 T117 L118 G119 A121 F145 H149 E150 H153 H159 L182 T114 L115 G116 A118 F142 H146 E147 H150 H156 L174 3.4.24.- 0004222,0006508,0008237 ic50=0.69nM Q9UHI8 21300546 2 SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNSHMMASMLNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCTCSTLWCTGTLVCQTKHFPWADGTSCGEGKWCINGKCVNKLVPR