3pz3 B 2.0 BS01 ZN B 1 D238 C240 H290 D231 C233 H283 H190 R232 K235 D238 C240 Y241 D280 D287 H290 H183 R225 K228 D231 C233 Y234 D273 D280 H283 2.5.1.60 0003824,0004659,0004661,0004663,0005515,0005968,0008270,0008318,0018344,0019840,0031267,0046872 Q08603 21520375 1 QKDVTIKSDAPDTLLLEKHADYIASYGSDYEYCMSEYLRMSGVYWGLTVMDLMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLQRVNVQPELVS 3pz3 B 2.0 BS02 CA B 1 H64 M66 H57 M59 H190 R232 K235 D238 C240 Y241 D280 D287 H290 H183 R225 K228 D231 C233 Y234 D273 D280 H283 2.5.1.60 0003824,0004659,0004661,0004663,0005515,0005968,0008270,0008318,0018344,0019840,0031267,0046872 Q08603 21520375 332 QKDVTIKSDAPDTLLLEKHADYIASYGSDYEYCMSEYLRMSGVYWGLTVMDLMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLQRVNVQPELVS 3pz3 B 2.0 BS03 PZ3 B 1 Y44 Y51 W52 L99 F147 D238 W244 P288 F289 H290 Y37 Y44 W45 L92 F140 D231 W237 P281 F282 H283 H190 R232 K235 D238 C240 Y241 D280 D287 H290 H183 R225 K228 D231 C233 Y234 D273 D280 H283 2.5.1.60 0003824,0004659,0004661,0004663,0005515,0005968,0008270,0008318,0018344,0019840,0031267,0046872 ic50=141nM -logKd/Ki=6.85, IC50=141nM Q08603 21520375 333 QKDVTIKSDAPDTLLLEKHADYIASYGSDYEYCMSEYLRMSGVYWGLTVMDLMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLQRVNVQPELVS