3pm0 A 2.7 BS01 HEM A 1 R117 M132 A133 R145 M152 I327 A330 S331 T334 L335 F394 V395 T398 I399 H401 I462 F463 S464 R468 C470 I471 S476 R50 M65 A66 R78 M85 I256 A259 S260 T263 L264 F323 V324 T327 I328 H330 I391 F392 S393 R397 C399 I400 S405 T334 F463 C470 T263 F392 C399 1.14.14.1,4.2.1.152 0001525,0002930,0004497,0005506,0005515,0005739,0005783,0005789,0006304,0006631,0006805,0006809,0007155,0007584,0008202,0008210,0008285,0008395,0008584,0008631,0009404,0009636,0010575,0014070,0014911,0016020,0016125,0016491,0016705,0016709,0016712,0016829,0019369,0019373,0020037,0030199,0030325,0030336,0032088,0032354,0032355,0033629,0042445,0042537,0042572,0042574,0043065,0043231,0043534,0043542,0044849,0045727,0045766,0046427,0046466,0046685,0046872,0048514,0048545,0061298,0061304,0061548,0070301,0070330,0071320,0071356,0071373,0071387,0071393,0071407,0071548,0071603,0071680,0097237,0097267,0101020,0106256,1904681,2000377,2000379,2000573 Q16678 21147782 900 QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLD 3pm0 A 2.7 BS02 BHF A 1 F134 N228 F231 L264 F268 D326 A330 T334 L509 F67 N161 F164 L197 F201 D255 A259 T263 L438 T334 F463 C470 T263 F392 C399 1.14.14.1,4.2.1.152 0001525,0002930,0004497,0005506,0005515,0005739,0005783,0005789,0006304,0006631,0006805,0006809,0007155,0007584,0008202,0008210,0008285,0008395,0008584,0008631,0009404,0009636,0010575,0014070,0014911,0016020,0016125,0016491,0016705,0016709,0016712,0016829,0019369,0019373,0020037,0030199,0030325,0030336,0032088,0032354,0032355,0033629,0042445,0042537,0042572,0042574,0043065,0043231,0043534,0043542,0044849,0045727,0045766,0046427,0046466,0046685,0046872,0048514,0048545,0061298,0061304,0061548,0070301,0070330,0071320,0071356,0071373,0071387,0071393,0071407,0071548,0071603,0071680,0097237,0097267,0101020,0106256,1904681,2000377,2000379,2000573 IC50=>10000nM, EC50=35000nM, Ki=16nM Q16678 21147782 800 QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLD