3pcf A 2.15 BS01 FHB M 1 G14 P15 G14 P15 Y79 V114 M122 H125 N127 Y79 V114 M122 H125 N127 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 -logKd/Ki=6.05, Ki=0.9uM P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pcf B 2.15 BS01 FHB N 1 G14 P15 G14 P15 Y79 V114 Y79 V114 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 -logKd/Ki=6.05, Ki=0.9uM P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pcf C 2.15 BS01 FHB O 1 G14 P15 G14 P15 Y79 V114 M122 H125 N127 Y79 V114 M122 H125 N127 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pcf D 2.15 BS01 FHB P 1 G14 P15 G14 P15 Y79 V114 Y79 V114 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pcf E 2.15 BS01 FHB Q 1 G14 P15 G14 P15 Y79 V114 M122 H125 N127 Y79 V114 M122 H125 N127 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pcf F 2.15 BS01 FHB R 1 G14 P15 R133 G14 P15 R133 Y79 V114 Y79 V114 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0042952,0051213 P00436 9254599 550 PIELLPETPSQTAGPYVHIGLALEAAGNPTRDQEIWNRLAKPDAPGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEYQDAYNLENAFNSFGRTATTFDAGEWTLHTVKPGVVNNAAGVPMAPHINISLFARGINIHLHTRLYFDDEAQANAKCPVLNLIEQPQRRETLIAKRCEVDGKTAYRFDIRIQGEGETVFFDF 3pcf M 2.15 BS01 FE M 1 Y408 Y447 H460 H462 Y105 Y144 H157 H159 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 P00437 9254599 600 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf M 2.15 BS02 FHB M 1 Y324 Y447 W449 R457 H460 H462 I491 Y24 Y144 W146 R154 H157 H159 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=0.9uM -logKd/Ki=6.05, Ki=0.9uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf M 2.15 BS03 FHB N 2 P322 I328 P22 I28 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=0.9uM -logKd/Ki=6.05, Ki=0.9uM P00437 9254599 551 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf N 2.15 BS01 FE N 1 Y408 Y447 H460 H462 Y105 Y144 H157 H159 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 P00437 9254599 600 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf N 2.15 BS02 FHB N 1 Y324 Y447 W449 R457 H460 H462 I491 Y24 Y144 W146 R154 H157 H159 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=0.9uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf N 2.15 BS03 FHB O 2 P322 I328 P22 I28 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=0.9uM P00437 9254599 551 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf O 2.15 BS01 FE O 1 Y408 Y447 H460 H462 Y105 Y144 H157 H159 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 P00437 9254599 600 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf O 2.15 BS02 FHB O 1 Y324 Y447 W449 R457 H460 H462 I491 Y24 Y144 W146 R154 H157 H159 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=0.9uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf P 2.15 BS01 FE P 1 Y408 Y447 H460 H462 Y105 Y144 H157 H159 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 P00437 9254599 600 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf P 2.15 BS02 FHB P 1 Y324 Y447 W449 R457 H460 H462 I491 Y24 Y144 W146 R154 H157 H159 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=0.9uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf P 2.15 BS03 FHB Q 2 P322 I328 P22 I28 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=0.9uM P00437 9254599 551 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf Q 2.15 BS01 FE Q 1 Y408 Y447 H460 H462 Y105 Y144 H157 H159 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 P00437 9254599 600 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf Q 2.15 BS02 FHB Q 1 Y324 Y447 W449 R457 H460 H462 I491 Y24 Y144 W146 R154 H157 H159 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=0.9uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf Q 2.15 BS03 FHB R 2 P322 I328 P22 I28 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=0.9uM P00437 9254599 551 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf R 2.15 BS01 FE R 1 Y408 Y447 H460 H462 Y105 Y144 H157 H159 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 P00437 9254599 600 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE 3pcf R 2.15 BS02 FHB R 1 Y324 Y447 W449 R457 H460 H462 I491 Y24 Y144 W146 R154 H157 H159 I188 Y408 Y447 R457 H460 H462 Y105 Y144 R154 H157 H159 1.13.11.3 0003824,0005506,0008199,0009056,0016702,0018578,0019619,0042952,0046872,0051213 Ki=0.9uM P00437 9254599 550 PAQDNSRFVIRDRNWHPKALTPDYKTSIARSPRQALVSIPQSISETTGPNFSHLGFGAHDHDLLLNFGLPIGERIIVAGRVVDQYGKPVPNTLVEMWQANAGGRYRHKNDRYLAPLDPNFGGVGRCLTDSDGYYSFRTIKPGPYPWRNGPNDWRPAHIHFGISGPSIATKLITQLYFEGDPLIPMCPIVKSIANPEAVQQLIAKLDMNNANPMDCLAYRFDIVLRGQRKTHFE