3p4q A 3.35 BS01 FAD A 1 G11 A12 A15 S36 K37 S43 H44 T45 A48 G50 G51 F156 V157 A191 T192 G193 D211 L242 H355 Y356 G378 E379 S393 S395 L396 L399 G12 A13 A16 S37 K38 S44 H45 T46 A49 G51 G52 F157 V158 A192 T193 G194 D212 L243 H356 Y357 G379 E380 S394 S396 L397 L400 A47 F116 T203 Q230 H232 L242 E245 R248 R287 H355 Y356 R390 A48 F117 T204 Q231 H233 L243 E246 R249 R288 H356 Y357 R391 1.3.5.1 0000104,0000166,0005515,0005829,0005886,0006113,0006974,0008177,0009055,0009061,0016020,0016491,0016627,0019645,0022900,0044780,0045283,0050660,0071949 P00363 21098488 601 MQTFQADLAIVGAGGAGLRAAIAAAQANPNAKIALISKVYPMRSHTVAAEGGSAAVAQDHDSFEYHFHDTVAGGDWLCEQDVVDYFVHHCPTEMTQLELWGCPWSRRPDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLQFPQIQRFDEHFVLDILVDDGHVRGLVAMNMMEGTLVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMALSHGVPLRDMEFVQYHPTGLPGSGILMTEGCRGEGGILVNKNGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRKGNTISTPRGDVVYLDLRHLGEKKLHERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRLAGEQATERAATAGNGNEAAIEAQAAGVEQRLKDLVNQDGGENWAKIRDEMGLAMEEGCGIYRTPELMQKTIDKLAELQERFKRVRITDTSSVFNTDLLYTIELGHGLNVAECMAHSAMARKESRGAHQRLDEGCTERDDVNFLKHTLAFRDADGTTRLEYSDVKITTLPPA 3p4q A 3.35 BS02 OAA A 1 G50 F116 H232 T244 E245 H355 R390 G51 F117 H233 T245 E246 H356 R391 A47 F116 T203 Q230 H232 L242 E245 R248 R287 H355 Y356 R390 A48 F117 T204 Q231 H233 L243 E246 R249 R288 H356 Y357 R391 1.3.5.1 0000104,0000166,0005515,0005829,0005886,0006113,0006974,0008177,0009055,0009061,0016020,0016491,0016627,0019645,0022900,0044780,0045283,0050660,0071949 -logKd/Ki=6.52, Ki=0.3uM P00363 21098488 702 MQTFQADLAIVGAGGAGLRAAIAAAQANPNAKIALISKVYPMRSHTVAAEGGSAAVAQDHDSFEYHFHDTVAGGDWLCEQDVVDYFVHHCPTEMTQLELWGCPWSRRPDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLQFPQIQRFDEHFVLDILVDDGHVRGLVAMNMMEGTLVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMALSHGVPLRDMEFVQYHPTGLPGSGILMTEGCRGEGGILVNKNGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRKGNTISTPRGDVVYLDLRHLGEKKLHERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRLAGEQATERAATAGNGNEAAIEAQAAGVEQRLKDLVNQDGGENWAKIRDEMGLAMEEGCGIYRTPELMQKTIDKLAELQERFKRVRITDTSSVFNTDLLYTIELGHGLNVAECMAHSAMARKESRGAHQRLDEGCTERDDVNFLKHTLAFRDADGTTRLEYSDVKITTLPPA 3p4q B 3.35 BS01 FES B 1 S56 C57 R58 A60 C62 G63 S64 C65 L75 C77 S56 C57 R58 A60 C62 G63 S64 C65 L75 C77 1.3.5.1 0005515,0005829,0005886,0006099,0006113,0008177,0009055,0009061,0016020,0016491,0019645,0044780,0045283,0046872,0051536,0051537,0051538,0051539 P0AC47 21098488 244 AEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTADQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR 3p4q B 3.35 BS02 F3S B 1 C158 P159 C204 F206 V207 G208 C210 I224 C158 P159 C204 F206 V207 G208 C210 I224 1.3.5.1 0005515,0005829,0005886,0006099,0006113,0008177,0009055,0009061,0016020,0016491,0019645,0044780,0045283,0046872,0051536,0051537,0051538,0051539 P0AC47 21098488 245 AEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTADQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR 3p4q B 3.35 BS03 SF4 B 1 C148 I149 N150 C151 G152 C154 A171 C214 P215 C148 I149 N150 C151 G152 C154 A171 C214 P215 1.3.5.1 0005515,0005829,0005886,0006099,0006113,0008177,0009055,0009061,0016020,0016491,0019645,0044780,0045283,0046872,0051536,0051537,0051538,0051539 P0AC47 21098488 246 AEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTADQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR 3p4q M 3.35 BS01 FAD M 1 G11 A12 G13 I35 S36 K37 S43 H44 T45 A47 A48 G50 G51 H155 F156 V157 A191 T192 G193 N204 I207 H355 Y356 E379 S393 S395 L396 L399 G12 A13 G14 I36 S37 K38 S44 H45 T46 A48 A49 G51 G52 H156 F157 V158 A192 T193 G194 N205 I208 H356 Y357 E380 S394 S396 L397 L400 F116 H232 R287 H355 Y356 R390 F117 H233 R288 H356 Y357 R391 1.3.5.1 0000104,0000166,0005515,0005829,0005886,0006113,0006974,0008177,0009055,0009061,0016020,0016491,0016627,0019645,0022900,0044780,0045283,0050660,0071949 P00363 21098488 601 MQTFQADLAIVGAGGAGLRAAIAAAQANPNAKIALISKVYPMRSHTVAAEGGSAAVAQDHDSFEYHFHDTVAGGDWLCEQDVVDYFVHHCPTEMTQLELWGCPWSRRPDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLQFPQIQRFDEHFVLDILVDDGHVRGLVAMNMMEGTLVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMALSHGVPLRDMEFVQYHPTGLPGSGILMTEGCRGEGGILVNKNGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRKGNTISTPRGDVVYLDLRHLGEKKLHERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRLAGEQATERAATAGNGNEAAIEAQAAGVEQRLKDLVNQDGGENWAKIRDEMGLAMEEGCGIYRTPELMQKTIDKLAELQERFKRVRITDTSSVFNTDLLYTIELGHGLNVAECMAHSAMARKESRGAHQRLDEGCTERDDVNFLKHTLAFRDADGTTRLEYSDVKITTLPPA 3p4q M 3.35 BS02 OAA M 1 F116 T244 E245 R287 H355 R390 F117 T245 E246 R288 H356 R391 F116 H232 R287 H355 Y356 R390 F117 H233 R288 H356 Y357 R391 1.3.5.1 0000104,0000166,0005515,0005829,0005886,0006113,0006974,0008177,0009055,0009061,0016020,0016491,0016627,0019645,0022900,0044780,0045283,0050660,0071949 P00363 21098488 802 MQTFQADLAIVGAGGAGLRAAIAAAQANPNAKIALISKVYPMRSHTVAAEGGSAAVAQDHDSFEYHFHDTVAGGDWLCEQDVVDYFVHHCPTEMTQLELWGCPWSRRPDGSVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLQFPQIQRFDEHFVLDILVDDGHVRGLVAMNMMEGTLVQIRANAVVMATGGAGRVYRYNTNGGIVTGDGMGMALSHGVPLRDMEFVQYHPTGLPGSGILMTEGCRGEGGILVNKNGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRKGNTISTPRGDVVYLDLRHLGEKKLHERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFAVGECSSVGLHGANRLGSNSLAELVVFGRLAGEQATERAATAGNGNEAAIEAQAAGVEQRLKDLVNQDGGENWAKIRDEMGLAMEEGCGIYRTPELMQKTIDKLAELQERFKRVRITDTSSVFNTDLLYTIELGHGLNVAECMAHSAMARKESRGAHQRLDEGCTERDDVNFLKHTLAFRDADGTTRLEYSDVKITTLPPA 3p4q N 3.35 BS01 SF4 N 1 C148 I149 N150 C151 G152 L153 C154 C214 V218 C148 I149 N150 C151 G152 L153 C154 C214 V218 1.3.5.1 0005515,0005829,0005886,0006099,0006113,0008177,0009055,0009061,0016020,0016491,0019645,0044780,0045283,0046872,0051536,0051537,0051538,0051539 P0AC47 21098488 244 AEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTADQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR 3p4q N 3.35 BS02 FES N 1 W55 C57 A60 I61 C62 G63 C65 C77 W55 C57 A60 I61 C62 G63 C65 C77 1.3.5.1 0005515,0005829,0005886,0006099,0006113,0008177,0009055,0009061,0016020,0016491,0019645,0044780,0045283,0046872,0051536,0051537,0051538,0051539 P0AC47 21098488 245 AEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTADQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR 3p4q N 3.35 BS03 F3S N 1 C158 C204 F206 V207 G208 C210 A221 I224 C158 C204 F206 V207 G208 C210 A221 I224 1.3.5.1 0005515,0005829,0005886,0006099,0006113,0008177,0009055,0009061,0016020,0016491,0019645,0044780,0045283,0046872,0051536,0051537,0051538,0051539 P0AC47 21098488 246 AEMKNLKIEVVRYNPEVDTAPHSAFYEVPYDATTSLLDALGYIKDNLAPDLSYRWSCRMAICGSCGMMVNNVPKLACKTFLRDYTDGMKVEALANFPIERDLVVDMTHFIESLEAIKPYIIGNSRTADQGTNIQTPAQMAKYHQFSGCINCGLCYAACPQFGLNPEFIGPAAITLAHRYNEDSRDHGKKERMAQLNSQNGVWSCTFVGYCSEVCPKHVDPAAAIQQGKVESSKDFLIATLKPR