3ozg A 1.993 BS01 SSI A 1 Y116 E144 D145 I146 D148 T149 G150 T152 K176 F197 V198 Y115 E143 D144 I145 D147 T148 G149 T151 K175 F196 V197 E144 D145 D148 F197 R210 E143 D144 D147 F196 R209 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Ki=0.65nM -logKd/Ki=9.19, Ki=0.65nM P20035 22726686 232 PIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKA 3ozg A 1.993 BS02 POP A 1 K77 G78 K114 S115 Y116 D204 R210 K76 G77 K113 S114 Y115 D203 R209 E144 D145 D148 F197 R210 E143 D144 D147 F196 R209 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 P20035 22726686 233 PIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKA 3ozg B 1.993 BS01 SSI B 1 Y116 E144 D145 I146 D148 T149 G150 T152 K176 F197 V198 Y116 E144 D145 I146 D148 T149 G150 T152 K176 F197 V198 E144 D145 D148 F197 R210 E144 D145 D148 F197 R210 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Ki=0.65nM P20035 22726686 233 MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKA 3ozg B 1.993 BS02 POP B 1 K77 G78 K114 Y116 R210 K77 G78 K114 Y116 R210 E144 D145 D148 F197 R210 E144 D145 D148 F197 R210 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 P20035 22726686 234 MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKA 3ozg C 1.993 BS01 SSI C 1 Y116 E144 D145 I146 D148 T149 G150 T152 F197 V198 L203 Y115 E143 D144 I145 D147 T148 G149 T151 F196 V197 L202 E144 D145 D148 F197 R210 E143 D144 D147 F196 R209 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Ki=0.65nM P20035 22726686 232 PIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL 3ozg C 1.993 BS02 POP C 1 K77 G78 Y116 R210 K76 G77 Y115 R209 E144 D145 D148 F197 R210 E143 D144 D147 F196 R209 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 P20035 22726686 233 PIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL 3ozg D 1.993 BS01 SSI D 1 Y116 E144 D145 I146 D148 T149 G150 T152 K176 F197 V198 Y116 E144 D145 I146 D148 T149 G150 T152 K176 F197 V198 E144 D145 D148 F197 R210 E144 D145 D148 F197 R210 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 Ki=0.65nM P20035 22726686 232 MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKA 3ozg D 1.993 BS02 POP D 1 K77 G78 R112 K114 Y116 D204 R210 K77 G78 R112 K114 Y116 D204 R210 E144 D145 D148 F197 R210 E144 D145 D148 F197 R210 2.4.2.22,2.4.2.8 0000166,0000287,0000310,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032265,0046100,0046872,0052657 P20035 22726686 233 MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYDIKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQSTGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPLWNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKA