3os9 A 2.303 BS01 KN1 A 1 L346 T347 E353 L40 T41 E47 ? IC50=1300nM P03372 20924370 1 ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLKSLEEKHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMVVPSYDLLLEMLDA 3os9 A 2.303 BS02 KN1 A 2 A350 D351 L384 M388 G521 L525 A44 D45 L78 M82 G212 L216 ? IC50=1300nM P03372 20924370 2 ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLKSLEEKHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMVVPSYDLLLEMLDA 3os9 B 2.303 BS01 KN1 B 1 L346 T347 L41 T42 ? IC50=1300nM P03372 20924370 1 LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMVVPSYDLLLEMLDA 3os9 B 2.303 BS02 KN1 B 2 A350 D351 W383 L384 L525 A45 D46 W78 L79 L211 ? IC50=1300nM P03372 20924370 2 LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMVVPSYDLLLEMLDA 3os9 C 2.303 BS01 KN1 C 1 L346 T347 E353 M421 L33 T34 E40 M102 ? IC50=1300nM P03372 20924370 1 SLALSLTADQMVSALLDAEPPILYSEYSMMGLLTNLADRELVHMINWAKRVPGFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSVVPSYDLLLEMLDA 3os9 C 2.303 BS02 KN1 C 2 A350 D351 L384 L387 G521 L525 A37 D38 L71 L74 G201 L205 ? IC50=1300nM P03372 20924370 554 SLALSLTADQMVSALLDAEPPILYSEYSMMGLLTNLADRELVHMINWAKRVPGFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSVVPSYDLLLEMLDA 3os9 D 2.303 BS01 KN1 D 1 A350 D351 L384 G521 A35 D36 L69 G192 ? IC50=1300nM P03372 20924370 1 LALSLTADQMVSALLDAEPPILYSESMMGLLTNLADRELVHMINWAKRVPGFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYVPSYDLLLEML 3os9 D 2.303 BS02 KN1 D 2 L346 E353 L391 F404 L31 E38 L76 F89 ? IC50=1300nM P03372 20924370 554 LALSLTADQMVSALLDAEPPILYSESMMGLLTNLADRELVHMINWAKRVPGFVDLTRHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYVPSYDLLLEML