3os3 A 2.8 BS01 ATP A 1 L74 G75 A76 G77 V82 A95 K97 M143 M146 S150 Q153 S194 L197 L13 G14 A15 G16 V21 A34 K36 M82 M85 S89 Q92 S133 L136 D190 K192 S194 N195 D208 D217 T226 D129 K131 S133 N134 D147 D156 T165 2.7.12.2 0004672,0005524,0006468 Q02750 21316218 1 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPMAIFELLDYIVNEPPPKLPVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCST 3os3 A 2.8 BS02 3OS A 1 G80 K97 L118 I141 R189 D208 F209 V211 L215 I216 M219 G19 K36 L57 I80 R128 D147 F148 V150 L154 I155 M158 D190 K192 S194 N195 D208 D217 T226 D129 K131 S133 N134 D147 D156 T165 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=6.63, IC50=235nM Q02750 21316218 400 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPMAIFELLDYIVNEPPPKLPVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCST 3os3 A 2.8 BS03 MG A 1 N195 D208 N134 D147 D190 K192 S194 N195 D208 D217 T226 D129 K131 S133 N134 D147 D156 T165 2.7.12.2 0004672,0005524,0006468 Q02750 21316218 401 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPMAIFELLDYIVNEPPPKLPVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCST