3orn A 2.8 BS01 ANP A 1 G75 G77 N78 V82 A95 K97 M143 M146 S150 Q153 K192 S194 L197 G15 G17 N18 V22 A35 K37 M83 M86 S90 Q93 K132 S134 L137 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 Q02750 21316218 1 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 3orn A 2.8 BS02 MG A 1 N195 D208 N135 D148 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 Q02750 21316218 2 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG 3orn A 2.8 BS03 3OR A 1 G80 K97 L118 V127 I141 R189 D208 F209 G210 V211 L215 I216 N221 G20 K37 L58 V67 I81 R129 D148 F149 G150 V151 L155 I156 N161 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=9.62, Kd=0.24nM IC50=8.8nM, Kd=0.24nM Q02750 21316218 400 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG