3ocb A 2.7 BS01 peptide C 0 E234 F236 D274 K276 L277 E278 F309 C310 G311 T312 P313 E314 Y315 L316 E341 Y350 E91 F93 D131 K133 L134 E135 F166 C167 G168 T169 P170 E171 Y172 L173 E198 Y207 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 P31749 20810279 1 ~ 10 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMRPHFPQFDYSASS 3ocb A 2.7 BS02 XM1 A 1 G162 K163 V164 A177 K179 M227 E228 A230 E234 E278 M281 T291 D292 F438 G19 K20 V21 A34 K36 M84 E85 A87 E91 E135 M138 T148 D149 F295 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=8.30, IC50=5nM IC50=5nM P31749 20810279 1 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMRPHFPQFDYSASS 3ocb B 2.7 BS01 peptide D 0 E234 F236 D274 K276 L277 E278 F309 C310 G311 T312 P313 E314 Y315 L316 E341 L347 E91 F93 D131 K133 L134 E135 F166 C167 G168 T169 P170 E171 Y172 L173 E198 L204 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 P31749 20810279 1 ~ 10 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITRPHFPQFDYSASS 3ocb B 2.7 BS02 XM1 B 1 G159 G162 A177 K179 M227 E278 N279 M281 T291 D292 F438 G16 G19 A34 K36 M84 E135 N136 M138 T148 D149 F295 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 IC50=5nM P31749 20810279 2 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITRPHFPQFDYSASS