3oad A 2.17 BS01 LPO A 1 T18 Q19 Y20 V36 D38 G40 W45 V46 H61 Y83 M114 F119 F124 D125 V127 T15 Q16 Y17 V33 D35 G37 W42 V43 H58 Y80 M111 F116 F121 D122 V124 D38 S41 N43 W45 Y83 D35 S38 N40 W42 Y80 3.4.23.15 0004190,0006508 ic50=0.24nM -logKd/Ki=9.62, IC50=0.24nM IC50=0.12nM P00797 20843686 167 GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 3oad B 2.17 BS01 LPO A 1 D226 G228 A229 D56 G58 A59 D226 A229 D56 A59 3.4.23.15 0004190,0006508 -logKd/Ki=9.62, IC50=0.24nM IC50=0.12nM P00797 20843686 167 SLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALARH 3oad C 2.17 BS01 LPO C 1 T18 Q19 D38 G40 W45 H61 L81 M114 P118 F119 F124 D125 V127 T18 Q19 D38 G40 W45 H61 L81 M114 P118 F119 F124 D125 V127 D38 S41 N43 W45 Y83 D38 S41 N43 W45 Y83 3.4.23.15 0004190,0006508 ic50=0.24nM IC50=0.12nM P00797 20843686 167 LTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRD 3oad D 2.17 BS01 LPO C 1 D226 G228 D56 G58 D226 A229 D56 A59 3.4.23.15 0004190,0006508 IC50=0.12nM P00797 20843686 167 SLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALARH