3nrz A 1.8 BS01 FES A 1 Q112 C113 G114 C116 C148 C150 Q111 C112 G113 C115 C147 C149 1.17.1.4,1.17.3.2 0005506,0016491,0046872,0051536,0051537 P80457 20615869 601 TADELVFFVNGKKVVEKNADPETTLLAYLRRKLGLRGTKLGCGEGGCGACTVMLSKYDRLQDKIIHFSANACLAPICTLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIEDAFQGNLCRCTGYRPILQGFRTFAK 3nrz A 1.8 BS02 FES A 2 G42 C43 G44 G46 C48 G49 C51 N71 C73 G41 C42 G43 G45 C47 G48 C50 N70 C72 1.17.1.4,1.17.3.2 0005506,0016491,0046872,0051536,0051537 P80457 20615869 602 TADELVFFVNGKKVVEKNADPETTLLAYLRRKLGLRGTKLGCGEGGCGACTVMLSKYDRLQDKIIHFSANACLAPICTLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIEDAFQGNLCRCTGYRPILQGFRTFAK 3nrz B 1.8 BS01 FAD B 1 K256 L257 V258 V259 G260 N261 T262 E263 I264 F337 V342 A346 S347 G350 N351 I353 T354 S359 D360 I403 L404 K33 L34 V35 V36 G37 N38 T39 E40 I41 F114 V119 A123 S124 G127 N128 I130 T131 S136 D137 I180 L181 1.17.1.4,1.17.3.2 0005506,0016491,0050660,0071949 P80457 20615869 606 PKQLRFEGERVTWIQASTLKELLDLKAQHPEAKLVVGNTEIGIEMKFKNQLFPMIICPAWIPELNAVEHGPEGISFGAACALSSVEKTLLEAVAKLPTQKTEVFRGVLEQLRWFAGKQVKSVASLGGNIITASPISDLNPVFMASGTKLTIVSRGTRRTVPMDHTFFPSYRKTLLGPEEILLSIEIPYSREDEFFSAFKQASRREDDIAKVTCGMRVLFQPGSMQVKELALCYGGMADRTISALKTTQKQLSKFWNEKLLQDVCAGLAEELSLSPDAPGGMIEFRRTLTLSFFFKFYLTVLKKLG 3nrz C 1.8 BS01 HPA C 1 E802 R880 F914 F1009 T1010 A1079 E232 R310 F344 F439 T440 A509 Q767 E802 R880 H884 R912 G1260 E1261 Q197 E232 R310 H314 R342 G690 E691 1.17.1.4,1.17.3.2 0005506,0016491,0043546 -logKd/Ki=5.34, Kd=4.6uM P80457 20615869 1 DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTGAPGNCK 3nrz J 1.8 BS01 FES J 1 Q112 C113 G114 C116 C148 C150 Q111 C112 G113 C115 C147 C149 1.17.1.4,1.17.3.2 0005506,0016491,0046872,0051536,0051537 P80457 20615869 601 TADELVFFVNGKKVVEKNADPETTLLAYLRRKLGLRGTKLGCGEGGCGACTVMLSKYDRLQDKIIHFSANACLAPICTLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIEDAFQGNLCRCTGYRPILQGFRTFAK 3nrz J 1.8 BS02 FES J 2 G42 C43 G44 G46 C48 G49 C51 N71 C73 G41 C42 G43 G45 C47 G48 C50 N70 C72 1.17.1.4,1.17.3.2 0005506,0016491,0046872,0051536,0051537 P80457 20615869 602 TADELVFFVNGKKVVEKNADPETTLLAYLRRKLGLRGTKLGCGEGGCGACTVMLSKYDRLQDKIIHFSANACLAPICTLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIEDAFQGNLCRCTGYRPILQGFRTFAK 3nrz K 1.8 BS01 FAD K 1 L257 V258 V259 G260 N261 T262 E263 I264 F337 V342 A346 S347 G350 N351 I353 T354 S359 D360 I403 L404 L34 V35 V36 G37 N38 T39 E40 I41 F114 V119 A123 S124 G127 N128 I130 T131 S136 D137 I180 L181 1.17.1.4,1.17.3.2 0005506,0016491,0050660,0071949 P80457 20615869 606 PKQLRFEGERVTWIQASTLKELLDLKAQHPEAKLVVGNTEIGIEMKFKNQLFPMIICPAWIPELNAVEHGPEGISFGAACALSSVEKTLLEAVAKLPTQKTEVFRGVLEQLRWFAGKQVKSVASLGGNIITASPISDLNPVFMASGTKLTIVSRGTRRTVPMDHTFFPSYRKTLLGPEEILLSIEIPYSREDEFFSAFKQASRREDDIAKVTCGMRVLFQPGSMQVKELALCYGGMADRTISALKTTQKQLSKFWNEKLLQDVCAGLAEELSLSPDAPGGMIEFRRTLTLSFFFKFYLTVLKKLG 3nrz L 1.8 BS01 HPA L 1 E802 R880 F914 F1009 T1010 A1079 E232 R310 F344 F439 T440 A509 H884 R912 E1261 H314 R342 E691 1.17.1.4,1.17.3.2 0005506,0016491,0043546 P80457 20615869 1 DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTT