3ncz A 3.0 BS01 3NC A 1 I82 A103 D202 N203 L205 A215 D216 I79 A100 D199 N200 L202 A212 D213 D198 K200 N203 D216 T237 D195 K197 N200 D213 T234 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=7.82, IC50=15nM Q13464 20678931 900 HMSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN 3ncz B 3.0 BS01 3NC B 1 I82 V90 A103 M153 N203 L205 D216 I79 V87 A100 M150 N200 L202 D213 D198 K200 N203 D216 T237 D195 K197 N200 D213 T232 2.7.11.1 0004672,0004674,0005524,0006468 Q13464 20678931 900 HMSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDVGTPDYISPEVLKSQGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDGEEETFPIPKAFVGNQLPFVGFTYYSN 3ncz C 3.0 BS01 3NC C 1 I82 V90 A103 V137 E154 Y155 M156 L205 A215 D216 I77 V85 A98 V132 E149 Y150 M151 L200 A210 D211 D198 K200 N203 D216 T237 D193 K195 N198 D211 T231 2.7.11.1 0004672,0004674,0005524,0006468 Q13464 20678931 900 HMSFEFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCTAVGTPDYISPEVLKSQGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEEETFPIPKAFVGNQLPFVGFTYYSNRR 3ncz D 3.0 BS01 3NC D 1 I82 G85 V90 A103 K105 N203 L205 D216 I77 G80 V85 A98 K100 N198 L200 D211 D198 K200 N203 D216 T237 D193 K195 N198 D211 T232 2.7.11.1 0004672,0004674,0005524,0006468 Q13464 20678931 900 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSN