3ms9 A 1.8 BS01 STI A 1 L248 Y253 A269 K271 E286 M290 T315 F317 M318 I360 H361 L370 A380 D381 F382 L23 Y28 A44 K46 E55 M59 T84 F86 M87 I129 H130 L139 A149 D150 F151 D363 A365 R367 N368 D381 P402 D132 A134 R136 N137 D150 P169 2.7.10.2 0004672,0004713,0005524,0006468 IC50=10.8nM P00520 20450175 1 AMDPPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 3ms9 A 1.8 BS02 MS9 A 1 A337 L340 L341 I432 A433 P465 V468 A106 L109 L110 I199 A200 P232 V235 D363 A365 R367 N368 D381 P402 D132 A134 R136 N137 D150 P169 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=5.22, Kd=6uM P00520 20450175 516 AMDPPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 3ms9 B 1.8 BS01 STI B 1 L248 Y253 V256 A269 K271 E286 M290 I313 T315 F317 M318 I360 H361 L370 A380 D381 F382 L25 Y30 V33 A46 K48 E60 M64 I87 T89 F91 M92 I134 H135 L144 A154 D155 F156 D363 A365 R367 N368 D381 P402 D137 A139 R141 N142 D155 P176 2.7.10.2 0004672,0004713,0005524,0006468 IC50=10.8nM P00520 20450175 1 AMDPSSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 3ms9 B 1.8 BS02 MS9 B 1 A337 L341 I432 A433 P465 A111 L115 I206 A207 P239 D363 A365 R367 N368 D381 P402 D137 A139 R141 N142 D155 P176 2.7.10.2 0004672,0004713,0005524,0006468 P00520 20450175 516 AMDPSSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ