3mo0 A 2.78 BS01 SAH A 1 M1105 G1106 W1107 S1141 Y1142 R1166 N1169 H1170 Y1211 F1223 R1226 M122 G123 W124 S158 Y159 R183 N186 H187 Y228 F240 R243 Y1124 Y1211 Y141 Y228 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 IC50=230nM Q9H9B1 20434463 101 RIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRH 3mo0 A 2.78 BS02 E11 A 1 D1131 A1134 D1135 E1138 D1140 L1143 D1145 R1214 F1215 K1219 D148 A151 D152 E155 D157 L160 D162 R231 F232 K236 Y1124 Y1211 Y141 Y228 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 -logKd/Ki=6.81, Kd=154nM Q9H9B1 20434463 2001 RIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRH 3mo0 A 2.78 BS03 ZN A 1 C1031 C1074 C1078 C48 C91 C95 Y1124 Y1211 Y141 Y228 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 1236 RIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRH 3mo0 A 2.78 BS04 ZN A 2 C1037 C1074 C1080 C1084 C54 C91 C97 C101 Y1124 Y1211 Y141 Y228 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 2 RIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRH 3mo0 A 2.78 BS05 ZN A 3 C1031 C1033 C1037 C1042 C48 C50 C54 C59 Y1124 Y1211 Y141 Y228 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 3 RIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRH 3mo0 A 2.78 BS06 ZN A 4 C1172 C1227 C1232 C189 C244 C249 Y1124 Y1211 Y141 Y228 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 4 RIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRH 3mo0 A 2.78 BS07 ZN A 5 H1027 H1076 H1185 H44 H93 H202 Y1124 Y1211 Y141 Y228 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 10 RIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRH 3mo0 A 2.78 BS08 E11 A 2 D1131 A1134 R1137 E1138 D1140 L1143 D1145 R1214 F1215 K1219 D148 A151 R154 E155 D157 L160 D162 R231 F232 K236 Y1124 Y1211 Y141 Y228 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 -logKd/Ki=6.81, Kd=154nM Q9H9B1 20434463 2002 RIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRH 3mo0 B 2.78 BS01 SAH B 1 M1105 W1107 S1141 Y1142 R1166 N1169 H1170 Y1211 F1223 C1225 R1226 M112 W114 S148 Y149 R173 N176 H177 Y218 F230 C232 R233 Y1124 Y1211 Y131 Y218 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 IC50=230nM Q9H9B1 20434463 102 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3mo0 B 2.78 BS02 E11 B 1 A1134 D1135 R1137 D1140 L1143 D1145 F1215 A141 D142 R144 D147 L150 D152 F222 Y1124 Y1211 Y131 Y218 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 2003 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3mo0 B 2.78 BS03 ZN B 1 C1031 C1044 C1074 C1078 C54 C67 C81 C85 Y1124 Y1211 Y131 Y218 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 5 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3mo0 B 2.78 BS04 ZN B 2 C1074 C1080 C1084 C81 C87 C91 Y1124 Y1211 Y131 Y218 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 6 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3mo0 B 2.78 BS05 ZN B 3 C1031 C1033 C1037 C1042 C54 C56 C60 C65 Y1124 Y1211 Y131 Y218 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 7 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3mo0 B 2.78 BS06 ZN B 4 C1172 C1227 C1232 C179 C234 C239 Y1124 Y1211 Y131 Y218 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 8 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3mo0 B 2.78 BS07 ZN B 5 H1027 H1076 H1185 H50 H83 H192 Y1124 Y1211 Y131 Y218 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 Q9H9B1 20434463 9 IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS