3mke A 1.75 BS01 MA4 A 1 V224 P226 A248 V261 I263 A284 V199 P201 A222 V234 I236 A257 S70 K73 S130 E166 K234 A237 S45 K48 S105 E141 K209 A212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 P0AD64 21041505 400 SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR 3mke A 1.75 BS02 MA4 A 2 L220 R244 N276 I279 L195 R218 N249 I252 S70 K73 S130 E166 K234 A237 S45 K48 S105 E141 K209 A212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 P0AD64 21041505 401 SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR 3mke A 1.75 BS03 CB4 A 1 M69 S70 D104 Y105 S130 N132 E166 N170 T235 G236 A237 M44 S45 D79 Y80 S105 N107 E141 N145 T210 G211 A212 S70 K73 S130 E166 K234 A237 S45 K48 S105 E141 K209 A212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 -logKd/Ki=5.66, Ki=2.2uM Ki=2200nM P0AD64 21041505 1 SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR 3mke A 1.75 BS04 CZ6 A 1 A79 R83 D88 F151 A54 R58 D63 F126 S70 K73 S130 E166 K234 A237 S45 K48 S105 E141 K209 A212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 P0AD64 21041505 293 SPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARGIVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR