3mj5 A 2.63 BS01 GRM A 1 L163 G164 D165 P248 P249 Y269 Q270 Y274 L160 G161 D162 P245 P246 Y266 Q267 Y271 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 -logKd/Ki=6.49, IC50=0.32uM IC50=320nM P0C6U8 20527968 801 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTI 3mj5 A 2.63 BS02 ZN A 1 C190 C193 C225 C227 C187 C190 C222 C224 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 P0C6U8 20527968 901 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTI 3mj5 A 2.63 BS03 GRM B 1 M209 G210 P248 Y269 M206 G207 P245 Y266 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 -logKd/Ki=6.49, IC50=0.32uM IC50=320nM P0C6U8 20527968 801 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTI 3mj5 B 2.63 BS01 GRM A 1 M209 G210 Y269 M155 G156 Y215 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 IC50=320nM P0C6U8 20527968 801 TFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIK 3mj5 B 2.63 BS02 GRM B 1 G164 D165 P249 Y265 Y269 Q270 Y274 T302 G110 D111 P195 Y211 Y215 Q216 Y220 T248 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 IC50=320nM P0C6U8 20527968 801 TFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIK