3mbl A 2.6 BS01 ADP A 1 G75 A76 G77 A95 K97 M143 M146 S150 Q153 S194 L197 G15 A16 G17 A35 K37 M83 M86 S90 Q93 S134 L137 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 Q02750 20621728 535 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 3mbl A 2.6 BS02 MG A 1 N195 D208 N135 D148 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 Q02750 20621728 536 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 3mbl A 2.6 BS03 LSG A 1 N78 K97 V127 I141 M143 D208 F209 G210 V211 S212 L215 I216 N18 K37 V67 I81 M83 D148 F149 G150 V151 S152 L155 I156 D190 K192 S194 N195 D208 D217 T226 D130 K132 S134 N135 D148 D157 T166 2.7.12.2 0004672,0005524,0006468 -logKd/Ki=7.74, IC50=0.018uM IC50=18nM Q02750 20621728 7 MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL