3lzb A 2.7 BS01 peptide F 0 R681 L754 Q767 R3 L76 Q89 D813 A815 R817 N818 D831 D135 A137 R139 N140 D153 2.7.10.1 0004672,0004713,0005524,0006468 P00533 20346655 8 ~ 14 LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG 3lzb A 2.7 BS02 ITI A 1 L694 V702 A719 K721 M742 C751 L753 L764 T766 M769 P770 F771 G772 L820 T830 D831 F832 L834 L16 V24 A41 K43 M64 C73 L75 L86 T88 M91 P92 F93 G94 L142 T152 D153 F154 L156 D813 A815 R817 N818 D831 D135 A137 R139 N140 D153 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=7.20, IC50=63nM Ki=32nM P00533 20346655 1 LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG 3lzb B 2.7 BS01 peptide E 0 R681 L754 R3 L76 D813 A815 R817 N818 D831 D135 A137 R139 N140 D153 2.7.10.1 0004672,0004713,0005524,0006468 P00533 20346655 7 ~ 15 LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG 3lzb B 2.7 BS02 ITI B 1 L694 V702 A719 K721 M742 C751 T766 M769 P770 F771 G772 L820 T830 D831 F832 L16 V24 A41 K43 M64 C73 T88 M91 P92 F93 G94 L142 T152 D153 F154 D813 A815 R817 N818 D831 D135 A137 R139 N140 D153 2.7.10.1 0004672,0004713,0005524,0006468 Ki=32nM P00533 20346655 1 LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG 3lzb C 2.7 BS01 peptide G 0 R681 W707 L754 R2 W28 L70 D813 A815 R817 N818 D831 D129 A131 R133 N134 D147 2.7.10.1 0004672,0004713,0005524,0006468 P00533 20346655 6 ~ 12 LRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG 3lzb C 2.7 BS02 ITI C 1 L694 V702 A719 K721 M742 C751 L753 T766 L768 M769 G772 L820 T830 F832 L834 L15 V23 A40 K42 M58 C67 L69 T82 L84 M85 G88 L136 T146 F148 L150 D813 A815 R817 N818 D831 D129 A131 R133 N134 D147 2.7.10.1 0004672,0004713,0005524,0006468 Ki=32nM P00533 20346655 1 LRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG 3lzb D 2.7 BS01 peptide H 0 R681 W707 Q767 R3 W29 Q85 D813 A815 R817 N818 D831 D131 A133 R135 N136 D149 2.7.10.1 0004672,0004713,0005524,0006468 P00533 20346655 5 ~ 13 LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG 3lzb D 2.7 BS02 ITI D 1 L694 V702 A719 K721 M742 C751 L753 T766 L768 M769 G772 L820 T830 D831 F832 L834 L16 V24 A41 K43 M60 C69 L71 T84 L86 M87 G90 L138 T148 D149 F150 L152 D813 A815 R817 N818 D831 D131 A133 R135 N136 D149 2.7.10.1 0004672,0004713,0005524,0006468 Ki=32nM P00533 20346655 1 LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQG