3lxe A 1.9 BS01 ZN A 1 H94 H96 H119 H90 H92 H115 H64 H94 H96 E106 H119 T199 H60 H90 H92 E102 H115 T195 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 P00915 20505865 261 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 3lxe A 1.9 BS02 TOR A 1 Q92 H94 H96 H119 L198 T199 H200 Q88 H90 H92 H115 L194 T195 H196 H64 H94 H96 E106 H119 T199 H60 H90 H92 E102 H115 T195 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 Ki=250nM -logKd/Ki=6.60, Ki=250nM Ki=250nM, IC50=250nM P00915 20505865 262 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 3lxe B 1.9 BS01 ZN B 1 H94 H96 H119 H90 H92 H115 H64 H94 H96 E106 H119 T199 H60 H90 H92 E102 H115 T195 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 P00915 20505865 261 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 3lxe B 1.9 BS02 TOR B 1 S65 Q92 H94 H96 H119 L198 T199 H200 S61 Q88 H90 H92 H115 L194 T195 H196 H64 H94 H96 E106 H119 T199 H60 H90 H92 E102 H115 T195 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 Ki=250nM Ki=250nM, IC50=250nM P00915 20505865 262 WGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF