3lw0 A 1.79 BS01 CCX A 1 M1054 V1063 M1079 H1133 L1174 M72 V81 M97 H142 L180 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 -logKd/Ki=6.40, IC50=0.4uM P08069 24900194 1 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 A 1.79 BS02 CCX A 2 Y1090 K1111 Q1114 M1115 E1118 F1147 E1271 P1272 Y108 K120 Q123 M124 E127 F156 E277 P278 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 -logKd/Ki=6.40, IC50=0.4uM P08069 24900194 1287 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 A 1.79 BS03 CCX D 2 G1273 V1277 G279 V283 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 -logKd/Ki=6.40, IC50=0.4uM P08069 24900194 1287 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 B 1.79 BS01 CCX B 1 M1054 V1063 M1079 H1133 R1134 L1173 L1174 F1189 M72 V81 M97 H142 R143 L179 L180 F195 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 P08069 24900194 2 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 B 1.79 BS02 CCX B 2 Y1090 K1111 M1115 E1118 D1146 F1147 E1271 P1272 Y108 K120 M124 E127 D155 F156 E277 P278 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 P08069 24900194 1287 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 B 1.79 BS03 CCX C 2 G1273 V1277 G279 V283 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 P08069 24900194 1287 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 C 1.79 BS01 CCX B 2 G1273 V1277 G279 V283 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 P08069 24900194 1287 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 C 1.79 BS02 CCX C 1 E1050 A1051 M1054 V1063 M1079 H1133 R1134 L1173 L1174 F1189 E68 A69 M72 V81 M97 H142 R143 L179 L180 F195 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 P08069 24900194 3 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 C 1.79 BS03 CCX C 2 Y1090 K1111 Q1114 M1115 E1118 D1146 F1147 E1271 P1272 Y108 K120 Q123 M124 E127 D155 F156 E277 P278 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 P08069 24900194 1287 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 D 1.79 BS01 CCX A 2 G1273 V1277 G279 V283 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 P08069 24900194 1287 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 D 1.79 BS02 CCX D 1 A1051 M1054 V1063 M1079 H1133 L1174 A69 M72 V81 M97 H142 L180 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 P08069 24900194 4 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 3lw0 D 1.79 BS03 CCX D 2 Y1090 K1111 Q1114 M1115 E1118 D1146 F1147 E1271 P1272 Y108 K120 Q123 M124 E127 D155 F156 E277 P278 D1135 R1139 N1140 D1153 E1162 D144 R148 N149 D162 E171 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 P08069 24900194 1287 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK