3lgp A 1.9 BS01 ZN A 1 H405 H409 H415 H182 H186 H192 3.4.24.86 0004222,0006508,0008237 P78536 20638281 1 PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS 3lgp A 1.9 BS02 50X A 1 T347 G349 L350 E398 L401 H405 E406 H409 H415 V434 Y436 P437 I438 A439 V440 S441 N447 T130 G132 L133 E175 L178 H182 E183 H186 H192 V211 Y213 P214 I215 A216 V217 S218 N224 3.4.24.86 0004222,0006508,0008237 Ki=2nM -logKd/Ki=8.70, Ki=2nM Ki=2nM P78536 20638281 485 PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQERS 3lgp B 1.9 BS01 ZN B 1 H405 H409 H415 H186 H190 H196 3.4.24.86 0004222,0006508,0008237 P78536 20638281 2 PMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQER 3lgp B 1.9 BS02 50X B 1 T347 G349 L350 E398 L401 H405 E406 H409 H415 V434 Y436 P437 I438 A439 S441 G442 N447 T128 G130 L131 E179 L182 H186 E187 H190 H196 V215 Y217 P218 I219 A220 S222 G223 N228 3.4.24.86 0004222,0006508,0008237 Ki=2nM Ki=2nM P78536 20638281 485 PMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECFQER