3kv2 A 1.55 BS01 MN A 1 D124 H126 D232 D234 D119 H121 D227 D229 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 P05089 20153713 514 RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 3kv2 A 1.55 BS02 MN A 2 H101 D124 D128 D232 H96 D119 D123 D227 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 P05089 20153713 515 RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 3kv2 A 1.55 BS03 NNH A 1 D124 H126 D128 S137 H141 D183 T246 D119 H121 D123 S132 H136 D178 T241 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 Kd=47.51nM -logKd/Ki=7.32, Kd=47.51nM Kd=47nM, IC50=1360nM P05089 20153713 901 RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 3kv2 B 1.55 BS01 MN B 1 D124 H126 D232 D234 D119 H121 D227 D229 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 P05089 20153713 514 RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 3kv2 B 1.55 BS02 MN B 2 H101 D124 D128 D232 H96 D119 D123 D227 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 P05089 20153713 515 RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 3kv2 B 1.55 BS03 NNH B 1 D124 H126 D128 S137 H141 D183 T246 D119 H121 D123 S132 H136 D178 T241 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 Kd=47.51nM Kd=47nM, IC50=1360nM P05089 20153713 902 RTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL