3kr1 A 2.3 BS01 SAH A 1 Y27 Y35 Y40 G79 S80 T83 Y85 D101 F102 N106 D158 V159 A181 F182 C183 V187 Y4 Y12 Y17 G56 S57 T60 Y62 D78 F79 N83 D135 V136 A158 F159 C160 V164 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 P11086 20642456 3001 ASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV 3kr1 A 2.3 BS02 VGD A 1 Y35 N39 R44 V53 F182 M258 Y12 N16 R21 V30 F159 M235 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 Kd=1.8uM -logKd/Ki=5.74, Kd=1.8uM P11086 20642456 290 ASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV 3kr1 B 2.3 BS01 SAH B 1 Y35 Y40 S80 T83 Y85 D101 F102 L103 N106 D158 V159 A181 F182 C183 V187 Y22 Y27 S67 T70 Y72 D88 F89 L90 N93 D145 V146 A168 F169 C170 V174 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 P11086 20642456 3002 PDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVG 3kr1 B 2.3 BS02 VGD B 1 N39 R44 V53 F182 Y222 M258 N26 R31 V40 F169 Y209 M245 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 Kd=1.8uM P11086 20642456 290 PDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVG