3kqa A 2.25 BS01 TR9 A 1 C115 A116 L138 C115 A116 L138 K22 N23 D49 R91 C115 R120 D305 H334 L370 R371 R397 K22 N23 D49 R91 C115 R120 D305 H334 L370 R371 R397 2.5.1.7 0003824,0005737,0008360,0008760,0009252,0016740,0016765,0019277,0051301,0071555 -logKd/Ki=4.85, IC50=14uM P33038 20392080 500 MDKFRVQGPTRLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDIDTTMKLLTQLGTKVERDGSVWIDASNVNNFSAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHIFGLEKLGAEIKLEEGYVKASVNGRLKGAHIVMDKVSVGATVTIMSAATLAEGTTIIENAAREPEIVDTANFLVALGAKISGQGTDRITIEGVERLGGGVYRVLPDRIETGTFLVAAAISGGKIVCRNAQPDTLDAVLAKLREAGADIETGEDWISLDMHGKRPKAVTVRTAPHPAFPTDMQAQFTLLNLVAEGTGVITETIFENRFMHVPELIRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE 3kqa B 2.25 BS01 TR9 B 1 C115 A116 K137 L138 C115 A116 K137 L138 K22 N23 D49 R91 C115 R120 D305 H334 L370 R371 R397 K22 N23 D49 R91 C115 R120 D305 H334 L370 R371 R397 2.5.1.7 0003824,0005737,0008360,0008760,0009252,0016740,0016765,0019277,0051301,0071555 P33038 20392080 500 MDKFRVQGPTRLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDIDTTMKLLTQLGTKVERDGSVWIDASNVNNFSAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHIFGLEKLGAEIKLEEGYVKASVNGRLKGAHIVMDKVSVGATVTIMSAATLAEGTTIIENAAREPEIVDTANFLVALGAKISGQGTDRITIEGVERLGGGVYRVLPDRIETGTFLVAAAISGGKIVCRNAQPDTLDAVLAKLREAGADIETGEDWISLDMHGKRPKAVTVRTAPHPAFPTDMQAQFTLLNLVAEGTGVITETIFENRFMHVPELIRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE 3kqa B 2.25 BS02 CA B 1 F104 Q106 F104 Q106 K22 N23 D49 R91 C115 R120 D305 H334 L370 R371 R397 K22 N23 D49 R91 C115 R120 D305 H334 L370 R371 R397 2.5.1.7 0003824,0005737,0008360,0008760,0009252,0016740,0016765,0019277,0051301,0071555 P33038 20392080 423 MDKFRVQGPTRLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDIDTTMKLLTQLGTKVERDGSVWIDASNVNNFSAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHIFGLEKLGAEIKLEEGYVKASVNGRLKGAHIVMDKVSVGATVTIMSAATLAEGTTIIENAAREPEIVDTANFLVALGAKISGQGTDRITIEGVERLGGGVYRVLPDRIETGTFLVAAAISGGKIVCRNAQPDTLDAVLAKLREAGADIETGEDWISLDMHGKRPKAVTVRTAPHPAFPTDMQAQFTLLNLVAEGTGVITETIFENRFMHVPELIRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE 3kqa C 2.25 BS01 TR9 C 1 C115 A116 L138 C115 A116 L138 K22 N23 D49 R91 C115 R120 D305 H334 L370 R371 R397 K22 N23 D49 R91 C115 R120 D305 H334 L370 R371 R397 2.5.1.7 0003824,0005737,0008360,0008760,0009252,0016740,0016765,0019277,0051301,0071555 P33038 20392080 500 MDKFRVQGPTRLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDIDTTMKLLTQLGTKVERDGSVWIDASNVNNFSAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHIFGLEKLGAEIKLEEGYVKASVNGRLKGAHIVMDKVSVGATVTIMSAATLAEGTTIIENAAREPEIVDTANFLVALGAKISGQGTDRITIEGVERLGGGVYRVLPDRIETGTFLVAAAISGGKIVCRNAQPDTLDAVLAKLREAGADIETGEDWISLDMHGKRPKAVTVRTAPHPAFPTDMQAQFTLLNLVAEGTGVITETIFENRFMHVPELIRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE 3kqa D 2.25 BS01 TR9 D 1 C115 A116 L138 C115 A116 L138 K22 N23 D49 R91 C115 R120 D305 H334 L370 R371 R397 K22 N23 D49 R91 C115 R120 D305 H334 L370 R371 R397 2.5.1.7 0003824,0005737,0008360,0008760,0009252,0016740,0016765,0019277,0051301,0071555 P33038 20392080 500 MDKFRVQGPTRLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDIDTTMKLLTQLGTKVERDGSVWIDASNVNNFSAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCAIGARPVDLHIFGLEKLGAEIKLEEGYVKASVNGRLKGAHIVMDKVSVGATVTIMSAATLAEGTTIIENAAREPEIVDTANFLVALGAKISGQGTDRITIEGVERLGGGVYRVLPDRIETGTFLVAAAISGGKIVCRNAQPDTLDAVLAKLREAGADIETGEDWISLDMHGKRPKAVTVRTAPHPAFPTDMQAQFTLLNLVAEGTGVITETIFENRFMHVPELIRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE