3km4 A 1.9 BS01 22X A 1 Q19 Y20 V36 D38 G40 P118 F119 L121 A122 F124 D226 G228 S230 Q16 Y17 V33 D35 G37 P115 F116 L118 A119 F121 D223 G225 S227 D38 S41 N43 W45 Y83 D226 A229 D35 S38 N40 W42 Y80 D223 A226 3.4.23.15 0004190,0006508 ic50=1.3nM -logKd/Ki=8.89, IC50=1.3nM IC50=1.3nM P00797 19959358 400 GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR 3km4 A 1.9 BS02 22X A 2 T18 A229 S230 Y231 F253 D254 F286 T297 H301 T15 A226 S227 Y228 F250 D251 F283 T294 H298 D38 S41 N43 W45 Y83 D226 A229 D35 S38 N40 W42 Y80 D223 A226 3.4.23.15 0004190,0006508 ic50=1.3nM -logKd/Ki=8.89, IC50=1.3nM IC50=1.3nM P00797 19959358 341 GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR 3km4 A 1.9 BS03 22X B 2 L117 F253 L114 F250 D38 S41 N43 W45 Y83 D226 A229 D35 S38 N40 W42 Y80 D223 A226 3.4.23.15 0004190,0006508 ic50=1.3nM -logKd/Ki=8.89, IC50=1.3nM IC50=1.3nM P00797 19959358 341 GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR 3km4 B 1.9 BS01 22X A 2 L117 F253 L114 F246 D38 S41 N43 W45 Y83 D226 A229 D35 S38 N40 W42 Y80 D219 A222 3.4.23.15 0004190,0006508 ic50=1.3nM -logKd/Ki=8.89, IC50=1.3nM IC50=1.3nM P00797 19959358 341 GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR 3km4 B 1.9 BS02 22X B 1 T18 Q19 Y20 V36 D38 G40 Y83 P118 F119 L121 A122 F124 V127 D226 G228 S230 M303 T15 Q16 Y17 V33 D35 G37 Y80 P115 F116 L118 A119 F121 V124 D219 G221 S223 M296 D38 S41 N43 W45 Y83 D226 A229 D35 S38 N40 W42 Y80 D219 A222 3.4.23.15 0004190,0006508 ic50=1.3nM -logKd/Ki=8.89, IC50=1.3nM IC50=1.3nM P00797 19959358 400 GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR 3km4 B 1.9 BS03 22X B 2 S230 Y231 D254 F286 T297 S223 Y224 D247 F279 T290 D38 S41 N43 W45 Y83 D226 A229 D35 S38 N40 W42 Y80 D219 A222 3.4.23.15 0004190,0006508 ic50=1.3nM -logKd/Ki=8.89, IC50=1.3nM IC50=1.3nM P00797 19959358 341 GNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR