3kej A 2.3 BS01 ZN A 1 H222 H226 H232 H119 H123 H129 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 20005097 901 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej A 2.3 BS02 ZN A 2 H172 D174 H187 H200 H69 D71 H84 H97 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 20005097 902 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej A 2.3 BS03 CA A 1 D179 G180 S182 L184 D202 E205 D76 G77 S79 L81 D99 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 20005097 903 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej A 2.3 BS04 CA A 2 D162 N194 D198 D59 N91 D95 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 20005097 904 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej A 2.3 BS05 CA A 3 D128 D203 E205 D25 D100 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 20005097 905 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej A 2.3 BS06 3EJ A 1 F217 L218 H222 L239 F241 I243 Y244 T245 Y246 T247 K249 F114 L115 H119 L136 F138 I140 Y141 T142 Y143 T144 K146 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=75.9nM -logKd/Ki=7.12, Ki=75.9nM Ki=76nM P45452 20005097 801 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej B 2.3 BS01 ZN B 1 H222 H226 H232 H113 H117 H123 H222 E223 H226 H232 H113 E114 H117 H123 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 20005097 901 TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej B 2.3 BS02 ZN B 2 H172 D174 H187 H200 H63 D65 H78 H91 H222 E223 H226 H232 H113 E114 H117 H123 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 20005097 902 TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej B 2.3 BS03 CA B 1 D179 G180 S182 L184 D202 E205 D70 G71 S73 L75 D93 E96 H222 E223 H226 H232 H113 E114 H117 H123 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 20005097 903 TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej B 2.3 BS04 CA B 2 D162 N194 G196 D198 D53 N85 G87 D89 H222 E223 H226 H232 H113 E114 H117 H123 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 20005097 904 TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej B 2.3 BS05 CA B 3 D128 E205 T206 D19 E96 T97 H222 E223 H226 H232 H113 E114 H117 H123 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 20005097 905 TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 3kej B 2.3 BS06 3EJ B 1 K140 N215 F217 L218 H222 A238 L239 F241 I243 Y244 T245 T247 K249 F252 K31 N106 F108 L109 H113 A129 L130 F132 I134 Y135 T136 T138 K140 F143 H222 E223 H226 H232 H113 E114 H117 H123 3.4.24.- 0004222,0006508,0008237,0008270,0031012 Ki=75.9nM Ki=76nM P45452 20005097 801 TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY