3jzf A 2.13 BS01 CO3 A 1 K238 R292 Q294 V295 E296 K169 R223 Q225 V226 E227 K116 H209 R235 T274 E276 E288 N290 R292 E296 R338 K116 H140 R166 T205 E207 E219 N221 R223 E227 R269 6.3.4.14 0003824,0003989,0004075,0005515,0005524,0005737,0005829,0006633,0009317,0016874,0042803,0045717,0046872,2001295 P24182 19875284 466 MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLGLQEK 3jzf B 2.13 BS01 JZK B 1 K116 K159 A160 G164 G166 R167 G168 M169 Y199 E201 K202 Y203 H209 H236 L278 I287 E288 K118 K161 A162 G166 G168 R169 G170 M171 Y201 E203 K204 Y205 H211 H238 L280 I289 E290 K116 K159 D196 H209 R235 T274 E276 E288 N290 R292 E296 R338 K118 K161 D198 H211 R237 T276 E278 E290 N292 R294 E298 R340 6.3.4.14 0003824,0003989,0004075,0005515,0005524,0005737,0005829,0006633,0009317,0016874,0042803,0045717,0046872,2001295 ic50=5uM -logKd/Ki=5.30, IC50=5uM P24182 19875284 466 RHMLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLG