3juk A 2.3 BS01 UPG A 1 A10 G11 E26 Q102 M105 G107 L108 A111 D131 Y170 G171 E190 K191 V203 A10 G11 E26 Q94 M97 G99 L100 A103 D123 Y162 G163 E182 K183 V195 2.7.7.9 0003983,0006011,0009058,0016779,0046872 -logKd/Ki=4.89, Kd=12.9uM O25363 20238176 282 MIKKCLFPAAGYGTRFLPITKTIPKEMLPIVDKPLIQYAVEEAMEAGCEVMAIVTGRNKRSLEDYFDTSYTNKENALKSIRNIIEKCCFSYVRQKQMKGLGHAILTGEALIGNEPFAVILADDLCISHDHPSVLKQMTSLYQKYQCSIVAIEEVALEEVSKYGVIRGEWLEEGVYEIKDMVEKPNQEDAPSNLAVIGRYILTPDIFEILSETKPGKNNEIQITDALRTQAKRKRIIAYQFKGKRYDCGSVEGYIEASNAYYKKRL 3juk B 2.3 BS01 UPG B 1 P8 A10 G11 E26 Q102 M105 G107 L108 A111 D131 Y170 G171 E190 V203 P8 A10 G11 E26 Q93 M96 G98 L99 A102 D122 Y161 G162 E181 V194 2.7.7.9 0003983,0006011,0009058,0016779,0046872 O25363 20238176 282 MIKKCLFPAAGYGTRFLPITKTIPKEMLPIVDKPLIQYAVEEAMEAGCEVMAIVTGRNKRSLEDYFDTSYNKENALKSIRNIIEKCCFSYVRQKQMKGLGHAILTGEALIGNEPFAVILADDLCISHDHPSVLKQMTSLYQKYQCSIVAIEEVALEEVSKYGVIRGEWLEEGVYEIKDMVEKPNQEDAPSNLAVIGRYILTPDIFEILSETKPGKNNEIQITDALRTQAKRKRIIAYQFKGKRYDCGSVEGYIEASNAYYKKR 3juk C 2.3 BS01 UPG C 1 P8 A10 G11 E26 Q102 M105 G107 L108 A111 D131 Y170 G171 E190 K191 V203 P8 A10 G11 E26 Q93 M96 G98 L99 A102 D122 Y161 G162 E181 K182 V194 2.7.7.9 0003983,0006011,0009058,0016779,0046872 O25363 20238176 283 MIKKCLFPAAGYGTRFLPITKTIPKEMLPIVDKPLIQYAVEEAMEAGCEVMAIVTGRNKRSLEDYFDTSYNKENALKSIRNIIEKCCFSYVRQKQMKGLGHAILTGEALIGNEPFAVILADDLCISHDHPSVLKQMTSLYQKYQCSIVAIEEVALEEVSKYGVIRGEWLEEGVYEIKDMVEKPNQEDAPSNLAVIGRYILTPDIFEILSETKPGKNNEIQITDALRTQAKRKRIIAYQFKGKRYDCGSVEGYIEASNAYYKKRL 3juk D 2.3 BS01 UPG D 1 P8 A10 G11 E26 Q102 M105 G107 L108 A111 L128 D131 Y170 G171 E190 K191 V203 P8 A10 G11 E26 Q94 M97 G99 L100 A103 L120 D123 Y162 G163 E182 K183 V195 2.7.7.9 0003983,0006011,0009058,0016779,0046872 O25363 20238176 284 MIKKCLFPAAGYGTRFLPITKTIPKEMLPIVDKPLIQYAVEEAMEAGCEVMAIVTGRNKRSLEDYFDTSYTNKENALKSIRNIIEKCCFSYVRQKQMKGLGHAILTGEALIGNEPFAVILADDLCISHDHPSVLKQMTSLYQKYQCSIVAIEEVALEEVSKYGVIRGEWLEEGVYEIKDMVEKPNQEDAPSNLAVIGRYILTPDIFEILSETKPGKNNEIQITDALRTQAKRKRIIAYQFKGKRYDCGSVEGYIEASNAYYKKR 3juk D 2.3 BS02 MG D 1 T14 R15 T14 R15 2.7.7.9 0003983,0006011,0009058,0016779,0046872 O25363 20238176 311 MIKKCLFPAAGYGTRFLPITKTIPKEMLPIVDKPLIQYAVEEAMEAGCEVMAIVTGRNKRSLEDYFDTSYTNKENALKSIRNIIEKCCFSYVRQKQMKGLGHAILTGEALIGNEPFAVILADDLCISHDHPSVLKQMTSLYQKYQCSIVAIEEVALEEVSKYGVIRGEWLEEGVYEIKDMVEKPNQEDAPSNLAVIGRYILTPDIFEILSETKPGKNNEIQITDALRTQAKRKRIIAYQFKGKRYDCGSVEGYIEASNAYYKKR